exogenous ligands

USAGE SUMMARY

"exogenous ligands" is a correct and usable term in written English.
It refers to molecules or compounds generated outside of an organism that bind to and activate certain proteins. An example sentence might be, "The cell responded to exogenous ligands by increasing its production of vasopressin."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

60 human-written examples

The exogenous ligands of these receptors are thiazolidinediones (TZDs), which are used to treat type 2 diabetes mellitus (DM2).

Regulatory Toxicology and Pharmacology

Different approaches were applied to study mechanism(s) which render AHR nuclear and design its function in absence of exogenous ligands.

Biochemical Pharmacology

The binding of exogenous ligands displaces the distal histidine and induces a conformational rearrangement involving the reorganization of internal void volumes.

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Therefore, the BBB is considered to be the major route for the uptake of endogenous and exogenous ligands into central nervous system.

Plosone

Since the BBB is considered to be the major route for the uptake of endogenous and exogenous ligands into central nervous system, we investigated intensively the BBB penetration.

Plosone

To test potential interaction site of EGCG in RIG-I, we tested RIG-I deletion mutants that can activate signal transduction in the absence of exogenous ligands.

Plosone

In contrast, ligands identified for the intracellular TLR3, TLR7, TLR8 and TLR9 mainly comprise exogenous ligands including double and single stranded RNA and CPG DNA.

Plosone

Therefore, cellular levels of PPARγ protein do not reflect the total activity of PPARγ or the capacity of exogenous ligands to overcome endogenous PPARγ activation.

Plosone

To establish a causal relationship between increased EGFR ligand levels and cetuximab resistance, we repeated cell proliferation assays in the presence of exogenous ligands (AREG, HB-EGF and TGFA) in the cetuximab sensitive cell line, SCC1 (Figure 3B).

Plosone

Thus, we investigated the effect of TLR2 and TLR4 activation by endogenous and exogenous ligands on the upregulation of the transcription factor HIF-1α, dendritic cell maturation and cytokine production in human monocyte-derived DC (MoDC) under normoxia.

Plosone

In turn, the tissue-specific GFP responses produced by these novel endogenous and exogenous ligands will also provide the bases for subsequent genetic, molecular and visual screens that provide new insights into how these tissues develop and function.

Plosone

Expert writing Tips

Best practice

When discussing receptor activation, clarify the origin of the ligands by specifying "exogenous ligands" to differentiate them from endogenous ones.

Common error

Avoid using "ligands" without specifying "exogenous" when you specifically mean ligands originating outside the organism. This prevents ambiguity and ensures clarity in scientific communication.

Linguistic Context

The phrase "exogenous ligands" functions as a noun phrase, typically serving as the subject or object of a sentence. As confirmed by Ludwig AI, it denotes substances originating from outside an organism or system that bind to and activate receptors.

Expression frequency: Very common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

The term "exogenous ligands" is a grammatically sound and highly prevalent phrase in scientific discourse. As Ludwig AI confirms, it refers to molecules originating outside an organism that bind to and activate specific receptors. Predominantly found in scientific sources, the phrase serves to clarify the external origin of these signaling molecules, distinguishing them from endogenous counterparts. To avoid ambiguity, writers should specify the origin of ligands, and ensure that the term "exogenous" is used correctly. Alternative phrases, such as "external signaling molecules", can be used to convey similar meanings.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

exogenous receptor modulators

This term simply replaces ligands with modulators, maintaining the exogenous origin.

external signaling molecules

This alternative focuses on the signaling aspect and the origin of the molecules.

introduced signaling molecules

This alternative focuses on the introduction of the signaling molecules.

foreign receptor agonists

This alternative specifies the agonistic nature of the ligands and their external origin.

introduced receptor activators

This phrase emphasizes the introduction of the activators and their target.

externally applied agonists

This emphasizes the application method and the agonistic action of the ligands.

non-native binding agents

This term highlights the foreign nature of the binding agents to the system.

outside-source modulators

This phrase describes the ligands as modulators originating from an external source.

artificially introduced signaling molecules

This alternative highlights the artificial or non-natural introduction of the signaling molecules.

synthetic receptor triggers

This focuses on the synthetic nature and triggering action of the ligands.

FAQs

How do I use "exogenous ligands" in a sentence?

"Exogenous ligands" are often used to stimulate or inhibit cellular processes. For instance, "The addition of "exogenous ligands" activated the receptor signaling pathway."

What's the difference between "exogenous ligands" and endogenous ligands?

"Exogenous ligands" originate from outside the body or system, while endogenous ligands are produced within the body. For example, drugs are examples of "exogenous substances", while hormones are "endogenous substances".

What are some examples of "exogenous ligands"?

Examples of "exogenous ligands" include drugs, toxins, and certain synthetic compounds that can bind to receptors within a biological system. Also, "bacterial products" may act as exogenous ligands.

What can I say instead of "exogenous ligands"?

Depending on the context, you could use phrases like "external signaling molecules" or "foreign receptor agonists" to convey a similar meaning.