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Exact(9)
Clearly, water-driven escalation occurred and tipping points were exceeded that in part have contributed to the situation as it stands today.
If DLTs were observed in ⩾2 of 3 or 6 patients, no further dose escalation occurred.
Dose escalation occurred after safety was established for at least 14 days from the previous cohort.
Dose escalation occurred in a 3+3 manner based on toxicity assessment.
Dose escalation occurred after six patients had completed at least one cycle of chemotherapy at the previous dose level.
Only after the current dose level had been judged to be safe were participants enrolled into the next cohort and dose escalation occurred.
Similar(51)
Escalation occurs whenever we invest our time, energy, or resources in a choice that falls short of the desired return, and we succumb to the temptation to invest more.
I usually go for a walk or do yoga when I start to feel even the smallest amount of stress -- experience has shown me how escalation occurs and I have learned to prevent it.
12 When dose escalation occurs, it is usually due to tolerance, progress of the disease 34 or opioid-induced hyperalgesia.
The aims of this study were to establish whether, and the extent to which, the phenomenon of risk escalation occurs in men who undergo targeted biopsy, by means of a computer simulation.
Here, we observed that de-escalation occurred in 44% of culture-negative patients without any negative impact on mortality.
Related(17)
scaling occurred
exacerbation occurred
intensification occurred
resurgence occurred
recrudescence occurred
amplification occurred
deterioration occurred
aggravation occurred
climbing occurred
build up occurred
climbers occurred
worsening occurred
escalation was
escalation followed
escalation required
escalation continued
escalation had
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com