Sentence examples for escalation required from inspiring English sources

Escalation required no serious adverse events.

Such trials would also be confounded by the natural crossover and treatment escalation required to appropriately treat progressive hyperglycemia.

The amount of dose escalation required to deem the biologic therapy ineffective, however, would most likely be employed in the event of clinically meaningful loss of efficacy.

Thus, with particle therapy, dose escalation required for long-term control of atypical or malignant meningiomas is feasible while adhering to normal tissue tolerance constraints.

Some fear Pyongyang would view any attack on its territory or military forces as an "escalation" requiring another round of attacks.

In the long run, however, the multipolar power system is likely to demise as have its predecessors due to a solidification of the existing alliances and a resulting decrease in the number of regime participants leading to an increased probability of conflict escalation requiring a new transformation.

It was hoped that this approach would reduce the number of dose escalations required to reach MTD.

Dose escalations required acceptable safety data based on blinded review of safety data at a dose-level review meeting following completion of the day 15/week 3 visit by the final patient in each cohort and when six or more patients in a cohort had been administered at least three doses of brodalumab (cohorts 1, 2, 3 and 5).

If only a first level of escalation was required then only an automated audio instruction with emphasis was provided and the system would move on to the next prompt relevant to the learners' position in the task.

Use of formulae to help guide drug dosing represents an attractive approach, although an ability to trigger both dose reduction and escalation is required.

Neither the subjects nor investigators were blinded once the saline formulation was removed from the trial, because only one formulation was used and because the dose-escalation design required that the safety of the 20 mcg dose be evaluated prior to administration of the 50 mcg dose.