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Aβ is known to be a toxic stimulus in a variety of model systems, and emerging experimental and clinical attempts to intervene in the disease process have shown preliminary success by preventing the production or enhancing clearance of the Aβ peptide [3], [4], [5], [6].

Understanding how to keep balance of tau homeostasis may enable identification of potential mechanisms for enhancing clearance of pathological forms of tau.

As previously discussed in the section on tg models, the conditional APP tg model showed that enhancing clearance of Aβ may actually be more critical than preventing its production when considering potential therapies.

Although there is no major treatment has been developed specifically for Huntington's disease, enhancing clearance of mHTT aggregates has been considered one of the feasible approaches to slow the neurodegeneration in Huntington's disease and has revealed some beneficial effects in animal models [ 34].

However, CD44 can increase the synthesis of chemokines such as IL-8 by enhancing clearance of the glycosaminoglycan hyaluronan [ 16], and it is not possible to determine whether the improvement in outcome in this model of lung injury was due to the effects of CD44 on clearance of apoptotic neutrophils or to the effect of CD44 on chemokine production.

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Intrapulmonary percussive ventilation physiotherapy with assisted autogenic drainage (IPV-AAD) is an emerging form of chest physiotherapy designed to enhance clearance of endobronchial secretions whilst enhancing alveolar recruitment.

Based on this evidence, we hypothesized that pharmacologic treatment with an inhaled beta-2 adrenergic agonist to enhance clearance of pulmonary edema from the distal airspaces would reduce donor hypoxemia and increase donor lung utilization.

Thus while brain CCL2 production may enhance beta-amyloidosis, peripheral CCL2 will enhance clearance.

An induction of CYPs via AHR signaling is to enhance clearance of these compounds.

Blocking CD200-CD200R interandion and stimulation of macrophage/microglia activation may enhance clearance of CNS myelin debris [36].

In contrast, IL-2 has been found to enhance clearance of Salmonella in the mouse raising the possibility that this cytokine is more important than IFNγ during the late response to Salmonella infection [77].

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