Sentence examples for endogenous presentation from inspiring English sources

We have generated a sensitive T cell hybridoma to functionally detect the endogenous presentation of a confirmed positive selecting self-pMHCII complex for a CD4+ transgenic T cell.

The rapid degradation of these polypeptides dramatically enhances endogenous presentation of peptide epitopes through the class I and II pathway.

Since many normal cells express MMP-2, it is important to understand the mechanisms that may prevent its endogenous presentation.

This can explain why deleted proteins have significantly better endogenous presentation of MMP-2 antigen than cysteine mutants.

Therefore endogenous presentation of the MMP-2 antigen can be induced by mutations impeding the formation of one disulfide bond within MMP-2 propeptide or fibronectin domain.

In this report, we provide evidence that disulfide bonds contained in the MMP-2 protein prevent endogenous presentation of the appropriate HLA-A2-restricted epitope.

Based on all of these results, it seemed inconceivable that a profound inhibition of endogenous antigen presentation would not affect T cell priming to at least some MCMV antigens if direct presentation were involved.

A comparison of the infected cells and peptide-pulsed cells in Fig. 5E indicated that K3 reduced endogenous p56 presentation approximately 10-fold.

The replication of H. pylori within the cells can explain the endogenous antigen presentation and activation of CD8+ T differentiation post infection.

However, the fact that MMP-2 C233A, which was secreted at a lower level (Fig. 3B) induced higher clone activation (Fig. 1B), suggests that protein secretion may nonetheless limit endogenous antigen presentation.

Exogenous bioactive TGF-β inhibits maturation and endogenous antigen presentation by immature human L-DC after antigen uptake [212], [214], and upregulates IL-10 secretion in T cells [215] and mDC [216] subsets (this includes L-DC [217]).