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Hookworm GSTs exhibit characteristic and unique heme binding properties required by the parasite to detoxify host heme released during blood feeding, hemolysis, and hemoglobin degradation., A vaccine comprised of Na-GST-1 that elicits neutralizing host antibodies, many of which are ingested by blood feeding hookworms, has shown promise in preclinical testing as a protective immunization strategy.
Another vaccine that elicits neutralizing antibodies is at an advanced stage of development.
The vaccine adjuvanted with MF59 elicits neutralizing antibodies (titer 1 91) after only 2 doses.
It is a major antigenic determinant that elicits neutralizing antibodies and cytotoxic T-lymphocyte immunity (3 ).
The ED3 domain from DENV2 (elicitsV2) elicits neutralizing antibodies and partial protection in monkey against the cognate virus [ 56].
Influenza virus surface glycoprotein hemagglutinin (HA) is an excellent and chief target that elicits neutralizing antibodies during vaccination or natural infection.
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Besides being non-infectious, due to the lack of the viral genome, VLPs resemble authentic viral particles in their unique structure (and size) and thereby also retain their ability to induce a strong B cell response, i.e. elicit neutralizing antibodies in the absence of adjuvants [ 6– 8].
Developing an effective HIV-1 vaccine that elicits broadly neutralizing HIV-1 human antibodies (bnAbs) remains a challenging goal.
With the recent limited performance of a major T-cell based vaccine trial [14], [15], there is renewed interest in vaccines that elicit neutralizing antibodies targeting conserved regions of Env such as the MPER [1], [2], [3], [4], [16], [17], [18].
In other words, RTB is poor in elicit antiricin neutralizing antibodies although it is highly immunogenic in eliciting nonneutralizing antiricin antibodies [ 24].
These findings strongly suggest that this structure-based designed epitope is effective in eliciting specific neutralizing antibodies against diverse HIV-1strains, including subtype C.
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