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Tetanus toxoid, a formalin-detoxified form of Clostridium tetani toxin adjuvanted in alumn, is a licensed human vaccine that induces neutralizing anti-tetanus toxin (TT) IgG antibodies.
It is also the first glycoprotein to be recognized by the immune system and induces neutralizing antibodies and cellular immunity.
The rabies virus (RV) glycoprotein (G protein) induces neutralizing antibodies, which are important in protection against rabies.
Prospect for prevention of human immunodeficiency virus infection: purified 120-kDa envelope glycoprotein induces neutralizing antibody.
We recently reported that a trimeric JRFL-gp120 immunogen, generated by inserting an N-terminal trimerization domain in the V1 loop region of a cyclically permuted gp120 (cycP-gp120), induces neutralizing activity against multiple tier-2 HIV-1 isolates in guinea pigs in a DNA prime/protein boost approach.
We have developed an inactivated virus vaccine that induces neutralizing antibodies and protects against SARS-CoV challenge.
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Yang et al. (25) reported that a candidate DNA vaccine encoding the full-length S protein induced neutralizing antibodies (neutralizing titers ranging from 1 50 to 1 150) and protected mice from SARS-CoV challenge.
Down-regulation of CD40L on CD4+ T cells is consistent with skin transplant tolerance induced by neutralizing CD40L function [6].
GP5 has six epitopes that can induce specific neutralizing antibodies.
The GP5 protein could induce specific neutralizing antibodies and serotype-specific linear epitopes could neutralize viral infections in vitro.
Briefly, gelation was induced by neutralizing the salt concentration and pH of the pepsin digests or collagen solution at 4 °C followed by warming to 37 °C.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com