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Exact(8)
Microwave (MW) treatment was used to develop a formulation process for the preparation of wet molded orally disintegrating tablets (ODTs) consisting of mannitol and polymeric disintegrant with improved hardness and disintegration properties.
In contrast, LFRF presented with prolonged in vivo disintegration properties.
In addition, the crystalline forms of mannitol impacted on hardness and disintegration properties of the ODT upon MW irradiation.
The MUPS based sustained-release domperidone formulation prepared using Celphere® 102 was found to possess rapid disintegration properties, hardness, and unaltered release profile even after compression.
Thus, both tablet hardness and disintegration properties of the molded tablets were improved by the proposed one-step method and the appropriate ranges for variables are indicated.
A surface response design with three formulation variables (binder, sorbitol and water level) and one process variable (spheronisation speed) was used to optimise the process and to evaluate pellet yield, sphericity (aspect ratio and two-dimensional shape factor, eR), size (mean Feret diameter), friability and disintegration properties.
Similar(52)
The scope of this study can be further extended to hydrophobic drugs, which may benefit from the rapid disintegration property and the use of various hydrophilic excipients used in the optimized pellet formulation to enhance dissolution and in turn improve bioavailability.
Among the various carriers, Aerosil 200 was found to provide desirable flow, compression, disintegration and dissolution properties.
The individual and combined effects of nature (N) and concentration of binder (C), and relative density of tablet (RD) on the mechanical tensile strength (TS) and friability (F) and drug release properties disintegration time (DT) and dissolution time (t80) of the tablets were investigated.
Besides the intrinsic antibacterial properties, disintegration of Cu nanoparticle through the settling on SiO2 particles will simultaneously lead to an efficient antibacterial activity of the surface fabricated.
In the preliminary part of the experiment, HPMC K15M mixed with gelatin was found to be the most suitable coating tablet material with respect to its disintegration and adherence properties.
Related(18)
erosion properties
division properties
decay properties
exclusion properties
decomposition properties
rupture properties
burst properties
disruption properties
breakdown properties
splitting properties
disintegration proceeds
disintegration products
unraveling properties
bursting properties
break up properties
disintegration paths
disintegration accelerators
disintegration times
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