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The designed visiometric liquid jet-mediated disintegration apparatus for RDT provided efficient and precise determination of very short disintegration times of rapidly disintegrating dosage forms.
Disintegration times increased with decreasing moving velocity.
The formulations were radiolabelled and followed by gamma scintigraphy; the disintegration times and positions were recorded.
The films were assessed for glucose release in vitro, swelling and disintegration times, and mucoadhesive ability.
Tablets were radiolabelled and followed by gamma scintigraphy; the disintegration times and positions were recorded.
Variation of the pellet size and the CoP/CuP ratio resulted in different in vitro tablet disintegration times.
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An updated compendium of different techniques employed to evaluate disintegrant action and measure disintegration time is also provided.
The independent factors selected were tablet hardness (X1), disintegrant (X2) and lubricant (X3) levels, and responses chosen were disintegration time (DT, Y1), friability (Y2), T50 (Y3), and T90 (Y4).
A major challenge in the development of orally disintegrating tablets (ODTs) is to achieve a good balance between tablet hardness and disintegration time.
Obtained dosage forms were characterized for drug content, disintegration time and mechanical properties.
Batches were characterised for moisture content, granule density, crushing strength, porosity, disintegration time and dissolution.
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