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Moreover, mutant male mice showed impaired glucose tolerance, yet without developing manifest diabetes.
However, small number of women developing manifest disease in population studies has often made it difficult to assess sex differences.
There are a number of risk factors for developing manifest cardiovascular disease, most important of which are age, family history, gender, smoking, diabetes, hypercholesterolemia, low physical activity and low consumption of fruit and vegetables [ 3].
Alkotob et al. (2006) reported for the first time that a PASP increase more than 40 mm Hg during exercise was associated with a higher risk of developing manifest PH [ 13].
A high burden of vascular risk factors means that an individual will have an increased risk of developing manifest end organ damage in the form of stroke, white matter lesions, vascular dementia, ischemic heart disease or claudication.
Similar(54)
The selected children were young and had not yet developed manifest contractures.
Regardless of the inoculum, all inoculated calves (n = 11), in both studies, developed manifest BRSV disease.
However, only two patients developed manifest CHF after completion of therapy (cumulative doxorubicin dose of 500 mg m−2).
We can't exclude that there might be patients in this group who will develop manifest personality disorders in the future.
Participants who had (subjectively) habituated to the noise could have developed manifest vascular changes in the longer term ["indirect" pathway (Babisch 2002)], for example, due to sleep disturbance (Basner et al. 2013).
Furthermore, it must be remembered that during a gluten challenge, some celiac patients may remain asymptomatic even if they develop manifest gluten-induced mucosal damage - this might in the long-run predispose these cases to celiac disease-related complications.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com