Exact(7)
Trans-cutaneous valve implantation (TAVI) has witnessed rapid evolution in terms of technical design, efficacy, and safety outcomes.
To address the within-subject correlation imposed by the crossover design, efficacy with respect to binary outcomes was tested in a conditional logistic regression model, stratified by subject, having main effects of period and treatment, with baseline pain severity as a covariate and with the interaction of period and the baseline covariate.
Published journal articles often contain the main outcomes of such studies but lack detailed data and information about study design, efficacy, and safety analysis, which might shed a different light on the results when analyzed by others; moreover, some trials aren't published at all.
Unicompartmental replacement of the knee for isolated medial or lateral arthrosis has been a controversial procedure regarding indications, design, efficacy, and longevity since its inception in the late 1950s.
Eligible studies were defined according to design (efficacy versus effectiveness) as Phase I (efficacy), Phase II (efficacy), or Phase III (effectiveness), and were also reviewed for methodological quality.
The results are summarized in tabular format in lieu of a formal metanalysis, as the latter was considered inappropriate due to the large variability in study design (efficacy or effectiveness), vaccine dosing schedule, vaccines used, and disease endpoints (IPD, AOM).
However, the study had several strengths compared with previous studies of voriconazole and other antifungals in this setting, such as the prospective study design, efficacy assessment based on imaging confirmed by a data review committee, treatment duration of 6 12 months, and a definition of global success that included only complete and partial radiological responses.
Similar(1)
O. Arancio designed efficacy studies, supervised experiments on the APP/PS1 Tg mice and drafted the manuscript.
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