These findings were subsequently confirmed in the similarly designed EMBOLDEN (Efficacy of Monotherapy Seroquel in BipOLarDepressioN) I and II trials (McElroy et al. 2010; Young et al. 2010).
Ongoing clinical trial (ONTARGET) has been designed the efficacy of telmisartan with an ACEI, ramipril, alone or in combination.
When this study was designed, the efficacy of new drugs in the second-line treatment of gastric cancer such as irinotecan and paclitaxel was unknown.
Although the study was not designed for efficacy, we argue that we did not approach the threshold of MAB cell dose requested for a larger cell engraftment and consequent clinical efficacy.
Trans-cutaneous valve implantation (TAVI) has witnessed rapid evolution in terms of technical design, efficacy, and safety outcomes.
Unicompartmental replacement of the knee for isolated medial or lateral arthrosis has been a controversial procedure regarding indications, design, efficacy, and longevity since its inception in the late 1950s.
To address the within-subject correlation imposed by the crossover design, efficacy with respect to binary outcomes was tested in a conditional logistic regression model, stratified by subject, having main effects of period and treatment, with baseline pain severity as a covariate and with the interaction of period and the baseline covariate.
Published journal articles often contain the main outcomes of such studies but lack detailed data and information about study design, efficacy, and safety analysis, which might shed a different light on the results when analyzed by others; moreover, some trials aren't published at all.
Eligible studies were defined according to design (efficacy versus effectiveness) as Phase I (efficacy), Phase II (efficacy), or Phase III (effectiveness), and were also reviewed for methodological quality.
