demonstrates proof of principle

USAGE SUMMARY

The phrase "demonstrates proof of principle" is correct and usable in written English.
It can be used in contexts where you want to indicate that something serves as evidence or validation of a concept or idea. Example: "The experiment demonstrates proof of principle for the new drug's effectiveness in treating the disease."

✓ Grammatically correct

Science

Academia

News & Media

Human-verified examples from authoritative sources

Exact Expressions

3 human-written examples

The observation that SSX4 is included within the synovial sarcoma gene set flagged in these analyses demonstrates proof of principle.

British Journal of Cancer

This is the first description of the prognostic value of this peptide in RCC and demonstrates proof of principle of the approach.

British Journal of Cancer

In the clinic, the success of HDAC inhibitors and DNA demethylating agents like aza cytidine as anti-cancer drugs demonstrates "proof of principle" of this approach and provides great hope for the development of a more comprehensive portfolio of "epigenetic drugs" in the future.

Clinical Epigenetics

Human-verified similar examples from authoritative sources

Similar Expressions

57 human-written examples

This study demonstrates proof-of-principle for the use of in vitro screening methods in allowing identification of pharmacological agents for utrophin transcriptional upregulation.

Plosone

While this clinical success demonstrates proof-of-principle, the clinical response is limited to a subset of patients.

BMC Systems Biology

Our work demonstrates proof-of-principle that identifying the genes that are upregulated in β3-null endothelial cells can identify novel modulators of angiogenesis.

DMM Disease Models and Mechanisms

The clinical benefit received by a subset of patients with metastatic melanoma demonstrates proof-of-principle for this therapeutic approach [ 3].

Breast Cancer Research

This is a very well thought, thorough study that in my mind demonstrates proof-of-principle, and for that reason is a strong contender for publication in eLife.

eLife

This demonstrates proof-of-principle for pharmacological inhibition of the SET1 family of chromatin-regulatory enzymes via disruption of protein protein interactions and serves as a starting point for further development of potential therapeutics that target WDR5-dependent complexesuchch as those found in MLL-rearranged leukaemias.

Biochemical Journal

In this study, our objective was to demonstrate proof-of-principle for RNAi therapy of a dominant myopathy in vivo.

Molecular Therapy

To demonstrate proof-of-principle measurement for physiologic change within an active myofascial trigger point (MTrP) undergoing trigger point release (ischemic compression).

Archives of Physical Medicine and Rehabilitation

Expert writing Tips

Best practice

Use "demonstrates proof of principle" when you want to emphasize that a concept or idea has been successfully tested or validated in a preliminary way. It's particularly useful when describing initial successes that pave the way for further development.

Common error

Avoid using "demonstrates proof of principle" if the evidence is weak or inconclusive. It's important to accurately reflect the strength of the evidence and not oversell the validation. Be sure that the evidence robustly supports the claim and avoid using this phrase to gloss over methodological flaws or small sample sizes.

Linguistic Context

The phrase "demonstrates proof of principle" serves as a declarative statement. It functions to assert that a particular action, study, or result provides evidence supporting the fundamental validity of a concept or approach. As confirmed by Ludwig, the phrase is grammatically sound and commonly used in academic and professional contexts.

Expression frequency: Uncommon

Frequent in

Science

70%

Academia

20%

News & Media

10%

Less common in

Formal & Business

0%

Encyclopedias

0%

Wiki

0%

Ludwig's WRAP-UP

The phrase "demonstrates proof of principle" is a grammatically correct and commonly used expression, as confirmed by Ludwig, primarily used in scientific, academic, and to a lesser extent, news contexts. It serves to highlight that a concept or approach has been successfully validated in a preliminary way, paving the path for further exploration and development. When using the phrase, be sure to accurately reflect the strength of the evidence and avoid overstating the strength of the demonstration. Alternatives like "proves the concept" or "validates the idea" can be used to convey a similar meaning.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

proves the concept

Focuses on the act of proving rather than demonstrating, implying a more conclusive validation.

validates the idea

Emphasizes the validation aspect, suggesting that the idea has been confirmed or supported.

confirms the hypothesis

More specific to scientific contexts, implying that a hypothesis has been tested and confirmed.

substantiates the claim

Highlights the substantiation of a claim, providing evidence to support its validity.

establishes the feasibility

Focuses on demonstrating that something is possible or practical.

provides evidence for the theory

Indicates that the presented information acts as evidence in favor of a specific theory.

shows the potential

Highlights the potential of something, demonstrating its capabilities or possibilities.

exemplifies the rationale

Indicates that something serves as an example of a particular reasoning or justification.

illustrates the mechanism

Focuses on clarifying the workings of a mechanism, demonstrating how it functions.

bears out the prediction

Implies that the prediction has been confirmed by the evidence or results.

FAQs

What does "demonstrates proof of principle" mean?

The phrase "demonstrates proof of principle" means to show that a concept or idea is feasible and has the potential to work. It signifies that initial evidence supports the concept, even if it requires further development and testing.

How can I use "demonstrates proof of principle" in a sentence?

You can use "demonstrates proof of principle" to highlight successful preliminary validation. For example: "This study "demonstrates proof of principle" for the use of in vitro screening methods".

What are some alternatives to "demonstrates proof of principle"?

Alternatives include "proves the concept", "validates the idea", or "confirms the hypothesis" depending on the context.

Is it appropriate to use "demonstrates proof of principle" in formal writing?

Yes, "demonstrates proof of principle" is suitable for formal writing, especially in scientific, academic, and business contexts. It is a clear and concise way to convey that an idea has been initially validated.