defining response

USAGE SUMMARY

The phrase "defining response" is correct and usable in written English.
It can be used in contexts where you are discussing a response that establishes or clarifies the meaning of something. Example: "The defining response to the question of climate change is that immediate action is necessary to mitigate its effects."

✓ Grammatically correct

Science

Academia

News & Media

Human-verified examples from authoritative sources

Exact Expressions

15 human-written examples

Pitfalls in the neuroimaging of glioblastoma in the era of antiangiogenic and immuno/targeted therapy - detecting illusive disease, defining response.

Harvard University

Defining response patterns by t-values (or in error-standard-deviation units) rather than by beta estimates (in % signal change) to define the patterns appeared advantageous.

NeuroImage

While loss of MITF is associated to resistance to MAPK inhibition43, expression of MITF and AXL was not associated to clinical benefit from ACT in our data; therefore, melanoma cell features such as lineage and differentiation may play a minor role in defining response to immunotherapy.

Nature

This was because no criteria are available for defining response of individual lesions.

EJNMMI Research

Table  2 shows an enumeration of the benefits of defining response from a methods perspective.

Arthritis Research and Therapy

Currently, there is no widely validated method for defining response to therapy.

Arthritis Research and Therapy

Human-verified similar examples from authoritative sources

Similar Expressions

45 human-written examples

Radiological response guidelines as defined by the Response Evaluation Criteria in Solid Tumours (RECIST) were used, defining responses after at least 8 weeks of therapy as either a complete response (CR), a PR, SD or PD.

British Journal of Cancer

We defined response as >50% decrease in Montgomery Åsberg Depression Rating Scale (MADRS) scores from baseline to trial end point13,14,15.

Nature

The experiments are designed in a user defined response surface methodology (RS M and are performed on the erosion tester.

Materials Today: Proceedings

We envision that ULP-WGS can be used in sequential samples during therapy to define response and progression but more importantly, those samples can be further analyzed for the specific resistant clones that emerge during therapeutic interventions in these patients.

Nature

We define response in terms of two conditions: reservoirs either below (under) or above (over) the saturation pressure that defines the permeability minima in the reservoir.

International Journal of Greenhouse Gas Control

Expert writing Tips

Best practice

When writing about research or medical treatments, clarify what metrics or criteria you are using when "defining response" to ensure clarity and avoid ambiguity. State if you are using established guidelines like RECIST or creating your own criteria.

Common error

Avoid using the phrase "defining response" without specifying how the response is being defined. A vague definition can lead to misinterpretations. For example, instead of simply saying 'We are "defining response"...', detail the exact criteria: 'We are "defining response" as a 50% reduction in tumor size'.

Linguistic Context

The phrase "defining response" functions as a verbal noun phrase, often serving as the object or subject of a sentence. As Ludwig AI illustrates, it's commonly used to denote the act of establishing criteria or metrics to measure and categorize reactions, particularly in scientific or clinical contexts.

Expression frequency: Uncommon

Frequent in

Science

70%

Academia

20%

News & Media

10%

Less common in

Formal & Business

0%

Encyclopedias

0%

Wiki

0%

Ludwig's WRAP-UP

The phrase "defining response" is a grammatically sound expression used to signify the act of establishing criteria for evaluating a reaction, particularly within scientific and medical domains. Ludwig AI confirms its correctness and usability. While the phrase appears in a formal register, it's important to use it with specific metrics or criteria to avoid ambiguity. Alternatives such as "establishing a response" or "determining the reaction" can be used for variety, though they may subtly shift the emphasis. In summary, "defining response" is a precise term that requires clear articulation of the criteria being used to evaluate an outcome.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

establishing a response

Focuses on the act of setting up or creating a response, rather than the act of defining what constitutes a response.

setting criteria for reaction

Places emphasis on establishing standards or benchmarks to assess and measure the reaction, differing slightly from simply clarifying it.

determining the reaction

Emphasizes the process of finding out the reaction, shifting the focus from the criteria that make up the response itself.

establishing parameters for the answer

Highlights the act of fixing the scope or nature of the answer, instead of solely defining what the response means.

deciding the response type

Focuses on selecting the type of response, rather than defining what constitutes the characteristics or measures of the response.

characterizing the outcome

Highlights the features and qualities of the result, differing from strictly defining the criteria of a response.

delineating the reply

Stresses the act of describing or portraying the reply in detail, shifting focus from explaining or giving clarity to it.

specifying the answer

Concentrates on the details of the answer or reply, moving away from the broader scope of a general 'response'.

prescribing reaction standards

Emphasizes mandating or suggesting what standards to use for the reaction, instead of clearly outlining the reaction's definition.

outlining the retort

Refers specifically to a sharp or witty reply, unlike the neutral 'response'.

FAQs

How is "defining response" typically used in medical contexts?

In medical contexts, "defining response" often involves setting specific, measurable criteria to determine if a treatment is effective. This could include changes in tumor size, symptom reduction, or improvement in lab values, as determined by established guidelines or study-specific parameters.

What are some standard methods for "defining response" in cancer treatment?

Common methods include the Response Evaluation Criteria in Solid Tumors (RECIST), which uses changes in tumor size to "define responses" as complete response (CR), partial response (PR), stable disease (SD), or progressive disease (PD). Other criteria may also be used depending on the specific cancer and treatment.

How does "defining response" differ from measuring the magnitude of a response?

"Defining response" sets the criteria for what constitutes a 'response' (e.g., a 50% reduction in symptoms), while measuring the magnitude involves quantifying how much the response occurred (e.g., a 75% reduction). "Defining response" establishes a threshold, while measuring quantifies the change.

Why is it important to be clear when "defining response" in research studies?

Clear definitions ensure that results are reproducible and comparable across different studies. Ambiguous definitions can lead to inconsistent findings and difficulties in interpreting the effectiveness of interventions. Standardized criteria also facilitate communication among researchers and clinicians.