critical alterations

USAGE SUMMARY

The phrase "critical alterations" is correct and usable in written English.
It can be used to refer to significant changes or modifications that are essential to a process, project, or situation. Example: "The project was delayed due to critical alterations in the design that needed to be addressed before moving forward."

✓ Grammatically correct

Science

Encyclopedias

Human-verified examples from authoritative sources

Exact Expressions

18 human-written examples

Deiuliis, J. et al. Visceral adipose inflammation in obesity is associated with critical alterations in T regulatory cell numbers.

Nature

Comprehensive analysis of cancer genomes has provided important insights in the critical alterations that confer proliferation and survival advantage to the tumor, so-called driver mutations.

Drug Resistance Updates

Materials from the oral tradition are the stuff of Lopes's literary storytelling: he makes critical alterations as he moves from the romance of the tale to the realism of the novel.

Encyclopedia Britannica

Overall, it is clear that the lack of gross changes in in vivo protein dynamics must obscure critical alterations in specific protein formation, such that combing protein measurements with global transcriptomics provides a powerful solution to understanding the nature of tissue remodelling in multiple organ failure patients.

Plosone

Colorectal carcinogenesis is associated with critical alterations of the Wnt/β-catenin signalling pathway.

BMC Cancer

Colorectal carcinogenesis is associated with critical alterations of the Wnt/β-catenin pathway involved in proliferation and survival.

BMC Cancer

Human-verified similar examples from authoritative sources

Similar Expressions

42 human-written examples

Identification of the specific p.Lys66Arg substitution in a significant portion of our pediatric-type follicular lymphoma cohort is highly suggestive of a common and critical alteration, leading to the disease development.

Nature

Though the variant 1911G was associated with elevated protein levels in a human kidney cell line expression system [23], the investigation of functional responses to capsaicin, pH and temperature in whole-cell patch-clamp and calcium imaging experiments suggests no critical alteration of receptor structure and function with respect to this receptor variant [24].

Plosone

In order to determine the optimal therapeutic target for future studies, the question that needs to be resolved is which of EGFR, FGFR2, and NKX2.1 is the most upstream and the critical alteration in primary gastric cancer.

Cancer Medicine

Proteolysis is a critical modification leading to alteration of protein function with important outcomes in many biological processes.

Methods in Enzymology

In this study, our principle hypothesis is that cellular networks are comprised of many functionally related modules, and that critical genomic alterations may not necessarily change expression themselves, but may affect downstream functional modules expression levels and perturb normal functionality, leading to significant phenotypic changes.

BMC Systems Biology

Expert writing Tips

Best practice

When using "critical alterations", ensure the context clearly indicates what is being altered and why these alterations are important. Providing specific details enhances clarity and impact.

Common error

Avoid using "critical alterations" without specifying the affected areas or the reasons for their criticality. Vague usage can weaken the statement and leave the reader uninformed.

Linguistic Context

The phrase "critical alterations" functions as a noun phrase, where "critical" modifies the noun "alterations". As Ludwig AI confirms, it's grammatically sound. It commonly acts as the subject or object of a sentence, indicating the focus on significant changes.

Expression frequency: Common

Frequent in

Science

85%

Encyclopedias

8%

Formal & Business

2%

Less common in

News & Media

1%

Reference

1%

Wiki

2%

Ludwig's WRAP-UP

The phrase "critical alterations" refers to significant and essential modifications. As Ludwig AI confirms, its usage is grammatically correct, predominantly appearing in scientific and academic contexts. The analysis reveals that while the phrase is appropriate for describing important changes, specificity in usage is key to maintaining clarity and impact. Common related terms include "key modifications" and "significant changes", which can be used as alternatives depending on the nuance required. Understanding these aspects allows for more effective and precise communication, particularly in technical or professional settings.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

key modifications

Focuses on essential modifications.

significant changes

Emphasizes substantial changes.

essential revisions

Highlights necessary revisions.

vital amendments

Stresses crucial amendments.

crucial adjustments

Underlines pivotal adjustments.

fundamental shifts

Implies basic shifts.

major transformations

Highlights big transformations.

pivotal modifications

Indicates key modifications.

important adjustments

Emphasizes relevant adjustments.

decisive changes

Highlights conclusive changes.

FAQs

How can I use "critical alterations" in a sentence?

You can use "critical alterations" to describe significant changes that are essential to a process or system. For example, "The project required "critical alterations" to meet the new safety standards".

What are some alternatives to saying "critical alterations"?

Alternatives include "key modifications", "significant changes", or "essential revisions" depending on the specific context.

Is it correct to say "critical alteration" instead of "critical alterations"?

While "critical alteration" can be correct, it refers to a single change. "Critical alterations" implies multiple changes or modifications are necessary or have occurred.

What is the difference between "critical alterations" and "minor adjustments"?

"Critical alterations" suggest substantial, essential changes, while "minor adjustments" refer to small, less impactful modifications. The choice depends on the magnitude and importance of the changes being described.