Because the patient displayed an atypical phenotype, including severe hair and nail manifestations, we scrutinized the exome sequencing data for additional potentially deleterious genetic variations in genes of relevance to the cornification process.
The epidermal α-keratins together with β-keratins function in the cornification process of the epidermal appendages of reptiles and birds (claws, scales, beaks, and feathers).
Likewise, the ratio of PI-positive cells and the frequency of cell internalization was not reduced by shRNA expression; only LDH release was suppressed, suggesting a role for this kinase in necrosis but not entosis and cornification processes.
Once activated, meprin β induces terminal differentiation and might therefore be involved in cornification, a unique process of cell death in which a water-impermeable barrier is formed.
3– 5 These extracellular lipid-enriched membranes are primarily responsible for the permeability barrier to water and electrolyte transit. 1, 2 In parallel with lipid matrix formation, keratinocyte cornification occurs, a process characterized by extensive cross-linking of loricrin, involucrin and other structural proteins by transglutaminases, leading to the formation of the cornified envelope.
Unlike previous observations based on MCF-10 A cells, the detached TertHMECs were found to have an apparent defect in the execution of apoptosis and instead, underwent non-apoptotic cell death through simultaneous entosis, cornification, and necrotic processes.
Our entire food supply has undergone a process of "cornification" in recent years, without our even noticing it.
FLG2 function is distinct from FLG [ 32] in the process of cornification.
Small proline rich (Sprr) proteins and late cornified envelope proteins (LCEs) are important for the process of cornification and contribute to barrier function formation (Martin et al, 2004).
Other up-regulated proteins like small proline rich protein 1B (SPRR1B), CD24, S100 calcium binding protein, SPARC, TFF1, SPRR1B and SERPINB13 also govern the wound healing process and cornification of epithelium, again, supporting the hypothesis of aberrant wound response in pterygium.
This is the case of cornification of the skin, a process discussed and reviewed by Candi et al. Cornification of the skin is a highly regulated temporal and spatial process of terminal differentiation of keratinocytes in which the resultant dead cells form a barrier in the uppermost layer of the skin.
