Sentence examples for epidermal differentiation process from inspiring English sources

The importance of an impaired epidermal differentiation process and skin barrier dysfunction in the pathogenesis of AE has recently been emphasized when a set of so-called "epidermal differentiation genes", including S100A7, S100A8, loricrin and filaggrin (FLG), was found to be differentially expressed in AE patients compared to healthy control individuals [14].

Indeed, this includes a delayed induction of genes that are responsible for cell signaling, DNA transcription, RNA translation, but also genes that are important for barrier function recovery such as those involved in epidermal differentiation process.

Of note, RNAPII ChIP-seq and RNA-seq profiles at the TP63 locus showed that Δ Np63 is the main isoform expressed in keratinocytes throughout the epidermal differentiation process, and the expression of the TAp63 isoform was not detected with both RNAPII ChIP-seq and RNA-seq methods (Supplementary Fig S1D).

We found that canonical Notch signaling is required for late-stage epidermal differentiation and correct processing of filaggrin, a process when perturbed being closely associated with barrier function defects and skin disorders.

In psoriasis-like skin lesions elicited in mice by IL-21, topical application of GED-0507-34L reduced cellular infiltrate and epidermal hyperplasia, normalizing the differentiation process.

K2 (formerly K2e, see before and Table  1) is another keratin specific for the advanced terminal differentiation process of epidermal keratinocytes.

MiR-203 was described as a 'stemness' repressor and an indirect promoter of differentiation process in epidermal keratinocytes, because of its ability to stop proliferation and block cell cycle at the G0/G1 phase.

The biological process of epidermal differentiation may reflect the basal-phenotype tumor origin.

We report here a transcriptome analysis of cervical tissue by SAGE, derived from 30,418 sequenced tags that provide a wealth of information about the gene products involved in normal cervical epithelium physiology, as well as genes not previously found in uterine cervix tissue involved in the process of epidermal differentiation.

We identified a core set of 196 genes that are differentially expressed between AK and cSCC, and are enriched for processes including epidermal differentiation, cell migration, cell-cycle regulation and metabolism.

Interestingly, on these two chromosomes, several loci with functional relevance for epidermal and keratinocyte differentiation processes, skin disorders and pigmentation-associated processes are clustered.