Sentence examples for completely defective from inspiring English sources

Importantly, the meiotic phenotype of dfp1-r35 suggests that disruption in prDSB formation is not its only defect, because rec12Δ mutants, which are completely defective for prDSB formation, nevertheless complete both meiotic divisions in with a normal timing and transcriptional program.

In Traf6 −/− cells, Q145N but not 2ED MAVS was completely defective in inducing IFNβ, but this defect was rescued by ectopic expression of WT but not C70A TRAF6.

Cytosolic extracts from Traf6 −/− primary MEF cells were severely, albeit not completely, defective in supporting IRF3 dimerization and IκBα phosphorylation in vitro, and these defects were rescued by adding back wild-type TRAF6.

"Maybe there's completely defective thinking [in the conventional view]," he says in the film.

Consistent with the result in Malt1 KO MEF cells, both CARMA3-deficient and BCL10-deficient cells were completely defective for NF-κB activation upon doxorubicin treatment.

The resulting constructs are functional, stably maintained under conditions where the original constructs are unstable, completely defective for conjugative transfer, and transferred via electroporation.

We found that, contrary to previous reports, rde-4 mutant animals are not completely RNAi defective.

Before testing whether cross-presentation could prime MCMV-specific CD8+ T cells, we needed to confirm that the ΔgL virus was completely spread defective.

We found that the nuclear RNAi and the FBF-1-mediated adaptation pathways function in parallel, such that double mutants are completely adaptation defective.

In line, other studies demonstrate that some of the PSEN1 FAD mutants, unlike wild-type human PSEN1 (hPSEN1) and its catalytically inactive forms, are unable to fully rescue altered Wnt signaling in PSEN-deficient cells [ 33] or completely alleviate defective epidermal growth factor receptor (EGFR) turnover in lysosomes, in a similar context [ 116].

The phenotype of both vertebrate cell lines is remarkably different: While ATG13−/− cells are completely autophagy defective, ULK1−/− ULK2−/− cells do not display any impairment of the autophagic pathway, indicating that ATG13 plays an essential role in autophagy induction, while ULK1/2 kinase activity is dispensable in this cell line.