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Exact(6)
All secondary outcome measures were compared between control and clinic arms directly.
For the primary outcome measure (patient knowledge score) mean scores were compared before and after clinic attendance in both the control and clinic arms using Student's t-test.
The difference between the control and clinic arms was not statistically significant (P=0.188); these data suggest that the pharmacy technician-led clinic detected more potential drug interactions but this hypothesis is unproven.
Both the control (home care) and experimental (clinic) arms were treated by the same team of specially trained nurses, and both followed the same evidence-based protocol for care including compression bandaging [ 21].
There were no statistically significant differences between the mean baseline scores in the control and clinic arms (P=0.942) or between second measurement and baseline in the control arm (P=0.822).
Actual regimens and cycle numbers for control and clinic arms are shown in Table 1; there was a significantly higher proportion of patients receiving adjuvant therapy in the clinical arm compared to the control (P=0.003, χ=9.074).
Similar(54)
In contrast, the difference from baseline in the clinic arm was very highly significant (P<0.001).
There were also more patients on regimens with greater emtogenicity in the clinic arm, notably FEC combinations (see Table 1).
The most common reason for delay was uncontrolled nausea and vomiting and there were notably more patients in the control arm (17) compared to the clinic arm (6).
More patients receiving trastuzumab monotherapy were randomised into the control rather than the clinic arm of the trial (13 vs two patients).
The mean cost of items wasted from previous supplies returned to the pharmacy by patients in the clinic arm of the study and subsequently destroyed was £26.70.
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