Further studies to evaluate sub-acute and chronic effect of this extract are recommended.
The upper gray line indicates a similar acute and chronic effect value, whereas the lower gray line indicates a 100-fold lower chronic effect level compared to the acute effect level.
The present study was designed to investigate the acute and chronic effect of MPD on the prefrontal cortex (PFC) neurons.
The ACR for the most sensitive aquatic trophic level (ACRaqu) is derived by comparing the lowest acute and chronic effect value of Daphnia and fish.
b Relationship between the acute (LC50) and chronic effect level of fish (NOEC) for industrial chemicals (filled symbol) and pesticides (open symbol).
A relationship between acute and chronic effect values of Daphnia (Fig. 1a) and fish (Fig. 1b) was demonstrated for industrial chemicals.
When these 54 units were rechallenged (chronic effect) with MPD, 39/54 (72%) exhibited reduction in their firing rate which can be interpreted as tolerance.
Adverse effects on other endpoints than male reproduction or possible chronic effect of multiple MRI scans have not been investigated in this study.
First, we assessed the acute and chronic effect of different doses of FIN (30 60 mg/kg) on LID, in male 6-OHDA-lesioned dyskinetic rats.
In addition, the chronic effect of HQT was also evaluated by coadministration of the 7th dose at 0.5 h before VPA.
This is the consequence of the acute effect of seizures and the chronic effect of epilepsy responsible for disrupting sleep architecture.
