checkpoint engagement

USAGE SUMMARY

The phrase "checkpoint engagement" is correct and usable in written English.
It can be used in contexts related to assessments, evaluations, or interactions at specific points in a process or project. Example: "During the project, we will have regular checkpoint engagement to ensure that we are on track and addressing any issues that arise."

✓ Grammatically correct

Science

News & Media

Academia

Human-verified examples from authoritative sources

Exact Expressions

7 human-written examples

Checkpoint engagement during anaphase is expected to inhibit the APC and consequently stabilize securin.

Current Biology

Prevention of cyclin B1 proteolysis at anaphase onset appears to be sufficient to cause mitotic checkpoint engagement and APC/CCdc20 inhibition in response to cohesin cleavage.

Current Biology

As a proxy for mitotic checkpoint engagement, we used the rapid recruitment of Mad2-EGFP to kinetochores upon microtubule depolymerization by nocodazole.

Current Biology

We finally tested whether Sli15INCENP dephosphorylation is indeed sufficient to prevent mitotic checkpoint engagement when tension between sister chromatids is lost at anaphase onset.

Current Biology

The corollary of this conclusion is that the inactivation of Cdk1 just prior to anaphase onset in normal cells could be responsible for preventing untimely checkpoint engagement caused by sister chromatids splitting.

Current Biology

The slow reaccumulation could be linked to the requirement for resynthesis and to only partial and slow inhibition of APC/CCdc20 [ 26, 27], which may help protect mitotic exit from the adverse effects of untimely mitotic checkpoint engagement in anaphase.

Current Biology

Human-verified similar examples from authoritative sources

Similar Expressions

53 human-written examples

These regulatory circuits include the engagement of inhibitory checkpoint pathways (CTLA-4, PD-1/PD-L1, LAG-3 and TIM-3), secretion of immunosuppressive cytokines (TGF-β, IL-10), and expansion and/or recruitment of myeloid or lymphoid regulatory cell populations.

Journal of Molecular Biology

This could lead to engagement of the pachytene checkpoint and meiotic arrest or sperm aneuploidy.

Human Reproduction Update

Preventing cyclin B1 proteolysis at the time of sister chromatid disjunction destabilizes kinetochore-microtubule attachments and triggers the engagement of the mitotic checkpoint.

Current Biology

Studies in Drosophila and yeast cells have shown that reversal of Cdk1 activity prevents engagement of the mitotic checkpoint in response to artificial sister chromatid disjunction [ 6, 7].

Current Biology

We found that the central event of anaphase, the separase-dependent disjunction of sister chromatids, can lead to the destabilization of kinetochore attachments and the engagement of a mitotic checkpoint response with potentially deleterious consequences.

Current Biology

Expert writing Tips

Best practice

In technical writing, define "checkpoint engagement" early, especially if the audience may not be familiar with the specific field.

Common error

Avoid using "checkpoint engagement" without context, especially in interdisciplinary settings. Always provide sufficient background or define the specific checkpoint being discussed to prevent confusion among readers from different fields.

Linguistic Context

The phrase "checkpoint engagement" primarily functions as a noun phrase, often acting as the subject or object in sentences related to biological or security contexts. Ludwig AI confirms its correct usage. For example, "mitotic checkpoint engagement" indicates a state or process.

Expression frequency: Uncommon

Frequent in

Science

64%

News & Media

25%

Academia

11%

Less common in

Formal & Business

0%

Encyclopedias

0%

Wiki

0%

Ludwig's WRAP-UP

In summary, the phrase "checkpoint engagement" is a noun phrase primarily used in scientific and technical contexts to describe the activation or involvement of a system's monitoring or regulatory mechanisms. Ludwig AI indicates that the phrase is grammatically correct and usable. While not exceedingly common, its usage is consistent across various academic and news sources. The most important recommendation for writers is to provide sufficient context when using the phrase, especially in interdisciplinary settings, to avoid ambiguity. Always consider defining the specific type of checkpoint being discussed to ensure clarity and prevent confusion among readers.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

Mitotic checkpoint activation

Focuses specifically on the activation aspect of the mitotic checkpoint, implying engagement but not directly stating it.

Immune checkpoint blockade

Specifies the blocking or inhibition of an immune checkpoint, contrasting with engagement.

Checkpoint pathway activation

Emphasizes the activation of the checkpoint pathway, similar to engagement but more focused on the biological process.

Spindle checkpoint activation

Highlights the activation of the spindle checkpoint, specifying a particular type of checkpoint.

Cell cycle checkpoint control

Concentrates on the control aspect of the cell cycle checkpoint rather than the engagement itself.

Checkpoint response initiation

Focuses on the initiation of a checkpoint response, differing from sustained engagement.

Checkpoint pathway inhibition

Describes the opposite action of engagement, focusing on the inhibition of the checkpoint pathway.

Mitotic surveillance mechanism

Refers to the broader surveillance mechanism in mitosis, not specifically the engagement of checkpoints.

Activation of surveillance mechanisms

Focuses on activating surveillance mechanisms more broadly, not just checkpoint engagement.

Checkpoint signaling

Highlights the signaling aspect of checkpoints without explicitly mentioning engagement.

FAQs

How is "checkpoint engagement" used in cell biology?

In cell biology, "checkpoint engagement" often refers to the activation of cellular mechanisms that monitor and regulate cell cycle progression, ensuring proper DNA replication and segregation. The "mitotic checkpoint", for instance, halts cell division if chromosomes are not correctly aligned.

What is the difference between "checkpoint engagement" and "checkpoint activation"?

"Checkpoint activation" describes the process of initiating a checkpoint response, while "checkpoint engagement" implies that the checkpoint is actively functioning and exerting its regulatory influence. "Checkpoint activation" is the initial step, whereas engagement is the sustained activity.

In the context of cancer, what does "checkpoint engagement" mean?

In cancer research, "checkpoint engagement" can refer to the activation of immune checkpoints, which are pathways that suppress the immune system's ability to attack cancer cells. Therapies targeting these checkpoints, such as "immune checkpoint inhibitors", aim to disengage these pathways and enhance anti-tumor immunity.

What are some synonyms for "checkpoint engagement" in a broader context?

Depending on the context, alternatives for "checkpoint engagement" could include "activation of regulatory mechanisms", "triggering of safety protocols", or "initiation of control processes". The best choice depends on the specific system or process being discussed.