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Limiting the activity of DNA ligase demands checkpoint activation for cell survival [7], [35].
In addition, we describe several key assays for studying checkpoint activation as well as methods for using small DNA structures to activate ATR.
Checkpoint Activation and Signaling.
thus reducing G2/M checkpoint activation.
The structural determinants of checkpoint activation.
Kai, M. & Wang, T.S. Checkpoint activation regulates mutagenic translesion synthesis.
DNA End Resection, Homologous Recombination and DNA Damage Checkpoint Activation Require CDK1.
However, uncoupling is not sufficient for checkpoint activation, and DNA synthesis by Polalpha is also required.
Using this structure, we examined the contribution of ds/ssDNA junctions and ssDNA to checkpoint activation.
Cytotoxicity was associated with profound cell cycle checkpoint activation and apoptosis induction.
Ira, G. et al. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1.
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