checkpoint assembly

USAGE SUMMARY

The phrase "checkpoint assembly" is correct and usable in written English.
It can be used in contexts related to project management, software development, or any process that involves a review or evaluation stage. Example: "Before we proceed to the next phase of the project, we need to conduct a checkpoint assembly to assess our progress and address any issues."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

2 human-written examples

A number of REST and CoREST target genes encode factors involved in cell cycle regulation (Table S3), including Mad2, an essential component of proper spindle checkpoint assembly that is regulated by ubiquitin ligase SCF beta-TrCP -dependent degradation of RESCF beta-TrCP -dependentf the cell cycle [76].

Plosone

For this purpose we used barley and wheat BAC sequences downloaded from NCBI, the HVGI gene indices (http://compbio.dfci.harvard.edu, V10) for barley as well as the rice genome (http://rice.plantbiology.msu.edu, V6.0) and the Brachypodium draft genome (http://www.brachypodium.org/, 4 × checkpoint assembly).

BMC Genomics

Human-verified similar examples from authoritative sources

Similar Expressions

57 human-written examples

Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension.

Nature

These results suggest that UbcH10 is potentially involved in the termination of the spindle assembly checkpoint and further implies that aberrant UbcH10 expression impairs the spindle assembly checkpoint resulting in chromosomal instability [ 11, 12].

BMC Cancer

Amongst those hits, the user finds "BubR1" (CG7838), a protein involved in the spindle assembly checkpoint that was shown to directly bind Fzy and also to localise to kinetochores when the spindle assembly checkpoint is active [ 20, 21].

BioData Mining

Roles for the conserved Spc105p/Kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.

Harvard University

Pangilinan, F. & Spencer, F. Abnormal kinetochore structure activates the spindle assembly checkpoint in budding yeast.

Nature

Lara-Gonzalez, P., Westhorpe, F. G. & Taylor, S. S. The spindle assembly checkpoint.

Nature

Foley, E. A. & Kapoor, T. M. Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore.

Nature

In prometaphase the APC/C becomes active again, but is controlled by the spindle assembly checkpoint.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Here, we report that BRCA2 regulates the spindle assembly checkpoint (SAC).

Developmental Cell

Expert writing Tips

Best practice

When discussing cell cycle regulation, use "checkpoint assembly" to specifically refer to the process of assembling the necessary components for a functional checkpoint.

Common error

Avoid using "checkpoint assembly" interchangeably with general "quality control" processes. "Checkpoint assembly" has a specific meaning within cellular biology and related fields. The term should be employed precisely when referring to the construction of a checkpoint mechanism.

Linguistic Context

The phrase "checkpoint assembly" functions primarily as a noun phrase, often serving as the subject or object in sentences describing cellular processes. Ludwig AI indicates its use in scientific contexts related to cell cycle regulation.

Expression frequency: Rare

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

In summary, "checkpoint assembly" is a noun phrase primarily used in scientific contexts to describe the process of constructing cellular checkpoints. While grammatically correct, its usage is relatively rare. Ludwig AI's analysis confirms its validity, and understanding its function and purpose is crucial for precise communication in fields like cell biology. Related phrases, such as "assembly checkpoint", offer alternative ways to express similar concepts, though the nuance of the process should be considered for accurate usage. It is important to use the term specifically, rather than overgeneralizing it to broader concepts of quality control.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

assembly checkpoint

Reverses the order of the words while maintaining the core meaning.

checkpoint construction

Substitutes "assembly" with "construction", focusing on the building aspect.

checkpoint formation

Replaces "assembly" with "formation", emphasizing the creation of the checkpoint.

spindle checkpoint formation

Adds 'spindle' to make the phrase more specific, referring to a certain type of checkpoint.

checkpoint complex formation

Specifies that a complex is being formed at the checkpoint.

establishment of checkpoint

Replaces "assembly" with a more formal phrase, "establishment of", indicating the setting up of a checkpoint.

checkpoint activation

Focuses on the activation or triggering of the checkpoint process.

implementation of checkpoint

Shifts the focus to the practical application of a checkpoint.

checkpoint mechanism initiation

Expands the concept to the initiation of a checkpoint mechanism.

checkpoint system setup

Uses more general terms to describe the setup of a checkpoint system.

FAQs

How is "checkpoint assembly" used in cell biology?

In cell biology, "checkpoint assembly" refers to the process by which the components of a cellular checkpoint—such as the spindle assembly checkpoint (SAC)—are brought together to form a functional unit that monitors and regulates cell division.

What is the difference between "checkpoint assembly" and "checkpoint activation"?

"Checkpoint assembly" refers to the construction or formation of the checkpoint mechanism, whereas "checkpoint activation" refers to the point when the checkpoint starts working and signaling in response to an issue (e.g. DNA damage).

What proteins are involved in "checkpoint assembly"?

The specific proteins involved in "checkpoint assembly" depend on the particular checkpoint being discussed. For example, the spindle assembly checkpoint involves proteins like Mad2, BubR1, and Mps1, which are critical for sensing chromosome attachment errors.

Is "assembly checkpoint" interchangeable with "checkpoint assembly"?

While the terms "checkpoint assembly" and "assembly checkpoint" are closely related, "checkpoint assembly" emphasizes the process of building the checkpoint, while "assembly checkpoint" refers to the checkpoint itself.