case of breakthrough

USAGE SUMMARY

The phrase "case of breakthrough" is not standard in written English and may be confusing without context.
It could be used in contexts discussing instances of significant progress or discovery, but it would typically require additional context to clarify its meaning. Example: "In the case of breakthrough innovations, companies must adapt quickly to stay competitive."

Science

News & Media

Formal & Business

Human-verified examples from authoritative sources

Exact Expressions

8 human-written examples

In the case of breakthrough infection, it is possible that any developed drug resistance mutants could revert back to wild-type in the absence of drug selection following the completion of PrEP.

Plosone

Opiates were used in both groups in the case of breakthrough pain.

Acta Orthopaedica

Opioids were used in both groups in the case of breakthrough pain.

Acta Orthopaedica

In the case of breakthrough disease activity despite a full and adequate course of a first-line preparation, switching to natalizumab, fingolimod or alemtuzumab should be considered.

European Journal of Neurology

For example, based on data from a Phase III clinical trial evaluating the efficacy of rifaximin in maintaining remission of HE episodes, for every four patients treated with rifaximin, approximately one case of breakthrough HE can be prevented.

ClinicoEconomics and Outcomes Research

In the case of breakthrough disease on first-line therapy, or rapidly evolving severe RRMS, second-line therapy with natalizumab, fingolimod or alemtuzumab should be chosen based on careful risk−benefit stratification.

European Journal of Neurology

Human-verified similar examples from authoritative sources

Similar Expressions

52 human-written examples

No cases of breakthrough candidal infection were observed with VOR prophylaxis.

BMC Infectious Diseases

In cases of clinically stable disease, switches to other non-interferon first-line treatments are recommended, but second-line treatment should be considered in cases of breakthrough disease.

European Journal of Neurology

Two cases of breakthrough candidaemia with C. glabrata were identified with blood cultures in a study of pre-emptive treatment by Maertens and colleagues [ 17].

European Journal of Clinical Microbiology and Infectious Diseases

With a theme of breakthrough cancer medicines, the conference featured an overview of the successful cases of breakthrough cancer medicines and regulatory considerations as well as effective early development that lays the foundation of breakthrough medication application.

Chinese Journal of Cancer

In addition, the number of cases of breakthrough aspergillosis in patients on azole prophylaxis will increase and certain manifestations of invasive aspergillosis, such as central nervous system aspergillosis, will be virtually untreatable as the use of voriconazole will be precluded.

Clinical Infectious Diseases

Expert writing Tips

Best practice

When using "case of breakthrough", ensure that the context clearly indicates what specific achievement or progress is being referred to. Be precise to avoid ambiguity.

Common error

Avoid using "case of breakthrough" as a generic term for any success. Use it when describing significant turning points or unexpected advancements. If the success is incremental, consider a different phrase.

Linguistic Context

The phrase "case of breakthrough" primarily functions as a prepositional phrase, often introducing an example or a specific situation that exemplifies a significant advancement or turning point. Ludwig's examples illustrate its use in describing medical advances, technological innovations, and strategic successes.

Expression frequency: Uncommon

Frequent in

Science

50%

News & Media

30%

Formal & Business

20%

Less common in

Academia

0%

Encyclopedias

0%

Wiki

0%

Ludwig's WRAP-UP

The phrase "case of breakthrough" is used to describe a particular instance where significant progress or advancement has been achieved. While grammatically acceptable and found in various contexts such as science, news, and business, Ludwig suggests that it's not the most common phrase and may benefit from being replaced with more direct alternatives depending on the context. The phrase serves to highlight specific achievements, but overuse or vagueness should be avoided for clarity. Remember to be precise in defining what achievement you are describing to avoid ambiguity. Common alternatives include "instance of breakthrough" or "example of progress".

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

instance of breakthrough

Replaces "case" with "instance" maintaining similar meaning while slightly changing the emphasis.

example of progress

Substitutes "breakthrough" with "progress", focusing on advancement rather than a sudden success.

instance of advancement

Replaces "case" with "instance" and "breakthrough" with "advancement" emphasizing a step forward.

example of success

Replaces "breakthrough" with "success", highlighting a positive outcome.

situation of innovation

Changes "breakthrough" to "innovation" focusing on the introduction of something new.

moment of discovery

Replaces "breakthrough" with "discovery", highlighting the finding of something new.

scenario of advancement

Combines the idea of a "scenario" and "advancement" to denote a specific context.

occasion of progress

Uses "occasion" instead of "case" placing the focus on a specific instance of forward movement.

circumstance of triumph

Emphasizes the victorious aspect by using "triumph" instead of "breakthrough".

achievement of advancement

Highlights the successful completion of advancement with the use of "achievement".

FAQs

What does "case of breakthrough" mean?

The phrase "case of breakthrough" refers to a specific instance or situation where a significant advancement, discovery, or success has been achieved, often unexpectedly or after overcoming challenges. It highlights a pivotal moment of progress.

How can I use "case of breakthrough" in a sentence?

You can use "case of breakthrough" to describe a specific situation where a significant advancement has occurred. For example, "In the "case of breakthrough innovation", companies must adapt quickly" or "The new drug represents a real "case of breakthrough" in cancer treatment".

Which is more appropriate, "case of breakthrough" or "instance of breakthrough"?

Both "case of breakthrough" and "instance of breakthrough" are grammatically correct. "Instance of breakthrough" might be slightly more common and direct, but "case of breakthrough" is also acceptable, particularly in formal writing.

What are some alternatives to "case of breakthrough"?

Depending on the context, you could use alternatives such as "example of progress", "moment of discovery", or "situation of innovation". The best choice depends on the specific nuance you want to convey.