Exact(3)
Like Dr. Fisher, their treatment could start with the oral drug Revlimid or the intravenous treatment, Velcade, followed by stem cell collection.
The remaining 25 percent have a more aggressive version of the disease, which the experts said should be treated more aggressively from the start, with Velcade followed by stem cell collection.
Subjects with stable or progressive disease were removed from the study, while those who responded received a third cycle followed by stem cell collection within 10 14 d of the third cycle.
Similar(5)
Induction therapy consisted of two rapidly cycled courses of CPA (2 g m−2) and EPI (120 mg m−2) with G-CSF supports followed by haematopoietic stem cell collection through leukaphereses.
Thus, nowadays, collection of HSC from the bone marrow (BM) has been neglected at least in the autologous transplantation setting and has been largely replaced by peripheral blood stem cell collection through cell separators.
Treatment consisted of one cycle of standard-dose VIP-chemotherapy (cisplatin 20 mg m−2, etoposide 75 mg m−2, ifosfamide 1200 mg m−2, daily for 5 days) plus granulocyte-colony stimulating factor (G-CSF) 5 μg kg−1 starting at day 7 followed by peripheral blood stem cell collection and subsequently three sequential cycles of HD-VIP chemotherapy.
The karyotype was sustained to be normal by the time of this stem cell collection.
Bone marrow infiltration by malignant plasma cells at diagnosis or at stem cell collection might serve as a surrogate marker for altered stem cell homeostasis.
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