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Activation of c-Kit by stem cell factor results in Mitf phosphorilation [8].
In Figure 2 we show an example to calculating the consistency value of an interaction taken from the pathway "Signaling events mediated by Stem cell factor receptor (c-Kit)", one of the NCI-Nature Curated pathways from the Pathway Interaction Database (PID [27].
We previously demonstrated that nilotinib-induced apoptosis was reduced by stem cell factor (SCF) addition.
The KIT gene (CD117) codes for a type III tyrosine-kinase receptor activated by stem cell factor (SCF).
The growth of MCs is mainly influenced by stem cell factor (SCF), which is produced by stromal cells, endothelial cells, and fibroblasts [ 80].
In contrast, Erk activation induced by stem cell factor, which activates c-Kit in the same cells, is sensitive to Raf inhibition and insensitive to PI3K and PKC inhibitors.
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The intrastriatal NPC transplantation in 6-OHDA-induced experimental PD rats induced behavioural recovery and protected from dopaminergic depletion by stem cells factor (SCF -mediated anti-apoptotic effectSCF -mediated
However in small cell lung cancer was demonstrated that the activation of c-kit by stem cells factor (SCF) leads to a predominantly HIF-1-alpha-mediated enhancement of VEGF expression and that inhibition of c-kit signalling with imatinib could result in inhibition of tumor angiogenesis [ 40].
Erythroid cell survival and proliferation are largely controlled by the hormone erythropoietin (Epo) [11] [13], but also by the stem cell factor, glucocorticoids, and bone morphogenetic protein-4 [14] [16].
Finally, the ability of the ECM-based scaffolds to efficiently support the growth of hematopoietic cells by releasing stem cell factor (SCF) was demonstrated.
We attempted to increase the number of positive cells by adding stem cell factor (SCF) to the culture, but this proved to be insufficient (Supplementary Fig S2A).
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