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This hypothesis is supported by recent data demonstrating similar retinal arteriolar and venular dilation after a single sublingual dose of 0.8 mg nitroglycerin between 20 patients with insulin-treated diabetes with no or only mild NPDR and 20 healthy age-matched control subjects (22).

The activity of nintedanib in CRC is further supported by recent data demonstrating similar efficacy and improved tolerability of nintedanib plus modified FOLFOX6 versus bevacizumab plus mFOLFOX6 in a randomised phase II study of 126 patients with previously untreated metastatic CRC [ 21].

This idea is supported by recent data demonstrating topographic Hox expression patterns with distinct boundaries in VSMCs and endothelial cells of adult blood vessels (Pruett et al., 2008); the spatial coordinates of these vascular Hox domains roughly correspond to the respective Hox domains during embryonic development (Pruett et al., 2008).

This hypothesis was further supported by recent data demonstrating that PKCα is involved in Akt activation in ECs [31], [32].

62 These findings were supported by recent data demonstrating that dolutegravir has essentially wild-type levels of activity against N155H and T97A + Y143R mutants, whereas its susceptibility was diminished by isolates containing G140S + Q148H, and was further diminished by those carrying G140S + Q148R.

Importantly, the potential ability of imatinib to slowly induce the elimination even of the LSC population is also suggested by recent data demonstrating that a certain percentage of patients, who achieve and keep CMR, have been able to discontinue imatinib without relapsing.

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Interestingly, there are recent data demonstrating decreases in invasive MRSA infections between 2005 and 2011 [ 20].

The metabolic products of the FASN complex are rapidly consumed by actively dividing cells and recent data demonstrates that FASN expression is important for tumor growth and survival, suggesting that FASN is a metabolic oncogene.

Although predominately mediated by VEGF-C and -D interaction with VEGFR3, recent data demonstrated elevated expression of tumor-derived VEGF-A contributes to pathological lymphangiogenesis [47] [48].

Recent data demonstrate that insulin reduces inflammation by activating anti-inflammatory signaling pathways, such as the phosphatidylinositol 3-kinase (PI3K /protein kinase B (Akt) pathway.

However, recent data demonstrates that polyglutamine tracts are degraded efficiently by eukaryotic proteasomes, thereby refuting the proposal that mutant polyglutamines block 26S proteasome function by becoming trapped inside the 26S proteasome [18].

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