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This was evidenced by histological data demonstrating that phagocytosed rhodopsin+ rods were predominantly negative for both early (activated caspase-3 and cleaved PARP) and late (TUNEL) markers of apoptosis, and by live-imaging observations of microglia phagocytosing predominantly PI-negative, rather than PI-positive, cells.
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This increase in cartilage matrix synthesis corresponded with increases in mechanical compressive nonlinear elastic properties and histological data demonstrating darker red Safranin-O staining.
This finding is in harmony with histological data demonstrating the emergence of adipocytes in the thymic lobes of senescent mice (Figure 2).
In accordance, our histological data demonstrated larger interfibrillar spaces in tendons from DM mice, and all of the aforementioned tendon-related genes were suppressed in Egr1-silenced tenocytes.
Histological data demonstrate a protective effect of HA on cartilage in various animal models of experimental OA.
Histological data demonstrated that Nestin represents a potential marker for SLCs, suggesting the possibility of isolating SLCs on the basis of Nes-GFP expression.
Finally, the anticancer effect of C60FAS was confirmed by histological data.
This is supported by data demonstrating improved survival with trastuzumab intracerebral microinfusion (ICM) in HER2-positive breast cancer xenografts, without evidence of clinical or histological toxicity, compared to intraperitoneal trastuzumab or ICM with saline [ 58].
New data demonstrates that the histological subtype – more so than the anatomical location – is an important independent prognostic factor.
Taken together, these data demonstrate that Dock3 attenuates both the histological and functional aspects of cuprizone-induced demyelination in optic nerves.
Taken together, these data demonstrate that Olig1 deficiency attenuates both the histological and functional aspects of EAE-induced optic neuritis.
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