Sentence examples for by precluding the binding from inspiring English sources

Intriguingly, the exogenous expression of known MCL-1-binding proteins such as PUMA and BIM2A has been shown to cause similar elevations of MCL-1 protein, likely by precluding the binding of BH3-only proteins such as NOXA and MULE, which are known to mediate the ubiquitylation and proteasomal degradation of MCL-1.

As a consequence, the A to G mutation prevents aminoglycoside binding by precluding the proper insertion of ring I into the binding site.

Similar levels of HSF1 DNA binding were observed for all the HSF1 mutants including the L189P mutant, suggesting that this mutation does not directly impinge on the function of the HSF1 DNA binding domain but rather imparts a genomic locus specific DNA binding defect, perhaps by precluding the interaction with auxiliary factors that are required for modulating loci-specific chromatin landscapes.

Phosphorylation of Atg13 by TOR precludes the binding of Atg13 to Atg1, resulting in a marked decrease in the kinase activity of Atg1 [11].

The orthotropic solutions have also been determined by precluding the bend twist coupling terms.

A dose-response EMSA showed that binding of one protein precludes the binding of another protein.

The interaction of Lgl with PAR-6 and aPKC precludes the binding of PAR-3 to PAR-6 and aPKC.

Taken as a whole, our results demonstrate that Tau phosphorylation in and around the PRD weakens the BIN1-Tau interaction by precluding SH3-PRD binding.