Sentence examples for by preventing the binding from inspiring English sources

By preventing the binding of HA to elastic fibers in COPD, lysozyme may interfere with the protective effect of this polysaccharide against enzymes and oxidants that degrade these fibers.

The finding of similar amounts of RelA and p50 proteins in the nucleus, but decreased NF-κB-DNA binding, even in those H RS cells characterized by mutations in the inhibitory IκB proteins, supports that B2 acts by preventing the binding of NF-κB to DNA.

It is present in solution as higher order complex structures and acts as a competitive inhibitor of FtsH by preventing the binding of CII.

The protein was originally regarded as an ortholog of CD59, which interfered with the assembling MAC by preventing the binding of C9 to the C5b-8 complex [18].

The antibody exerts its biologic activity by preventing the binding of BLyS to its receptors [ 19].

Our results suggest that methylation represses gene expression mainly by preventing the binding of CpG binding activators.

The AP-2 and Ets sites have been targeted by either preventing the binding of the cognate binding protein (using sodium aurothiomalate for AP-2 [ 16] and DNA-binding polyamides for Ets factors [ 17]) or by creating fusion proteins between the appropriate DNA-binding domain and a transcriptional repressor [ 4], in all cases impairing promoter activity in functional assays.

Class II RTKIs, such as sorafenib, bind to the non-active conformation of the receptor at the hydrophobic pocket of the activation loop and inhibit kinase activity by indirectly preventing the binding of ATP (Gotink and Verheul, 2010; Davis et al., 2011).

One suggested scenario is that CpG-SNPs can affect local DNA methylation which, in turn, affects the expression of a gene by allowing or preventing the binding of CpG methyl-binding proteins [ 13].

Sclerostin has been shown to be made by mature osteocytes and inhibits Wnt/ β-catenin signaling by binding to LRP5 and preventing the binding of Wnt.

REV-ERBα and REV-ERBβ act as negative transcriptional regulators by binding RORE in gene promoters, preventing the binding of the positive transcriptional regulator RORα, and negatively regulating the expression of ARNTL, CLOCK, and CRY1[ 47] 47].