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Notably, as predicted by our computational model, increased IRF3 phosphorylation and induction of Cxcl10 and Ifit2 mRNAs was observed for MyD88-deficient macrophages (Figure 3A C).
Incompletely and completely trained animals were studied because of the distinct events predicted by our computational model at different learning stages.
Such trends are also predicted by our computational model.
A schematic representation of the apoptotic signaling network described by our computational model is shown in Figure 1B.
The overall distribution trend of experimentally determined nucleosome occupancy around both start positions and end positions of pseudogenes is reproduced successfully by our computational model.
Abnormal functional levels of BRCA1 in prostate cancer may also cause activation or inhibition of STAT3 (signal transducer and activator of transcription 3) [ 37], which is predicted by our computational model.
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Ribonuclease T1 mapping confirmed that the wild-type XBP1-BLS and XBP1-BSL NZ assume similar structures, as predicted by our computational modeling (Fig EV4B).
We validate our computational model by showing that it produces outputs which conform to those produced by experiment.
Moreover, our computational model has been developed by incorporating the functional domain information through the hybridization model.
Moreover, our computational model has been developed by incorporating the functional domain composition of proteins through a hybridization model.
Our computational models, calibrated by experimental measurements, could be used as a virtual tool for assessing the mechanism of blast-panel interactions, and predicting the structural response of composite panels subjected to blast loading.
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