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HNRNPH1 and CLK1, two trans-acting splicing regulator factors, are predicted by our computational analysis to be differentially spliced between tumor cells.
Guided by our computational analysis, we tested and experimentally confirmed the expression of 4 novel small RNAs in Mtb.
Several of these had not had both mate-pair BES available previously and hence would have been undetectable by our computational analysis.
For S. cerevisiae this has not been reported, and as shown by the trancriptome profiling studies for S. cerevisiae secretion stress [ 2, 17- 19] and by our computational analysis (Table 1), only a few secreted proteins show down regulation in their transcript amounts under secretion stress in S. cerevisiae.
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A total of 456 of the 802 associations identified by computational analysis in our study have been previously proposed in the literature, thereby supporting our computational approach (supplementary material Table S2).
Our experimental data from microarray is supported by both computational analysis and literature searches, where differentially expressed gene signatures are shown to promote the malignant CRC process.
We compare the proposed hybrid approach with the traditional analytical model and simulation-based optimization model to understand their differences along with their advantages and disadvantages in a practical decision making context by presenting our findings with computational analysis.
Our own strategy is focused on testing the drugs and treatments proposed by the computational analysis of genomic information in animal models as a key clinical element.
By a computational analysis of sequence data, we examined patterns of variability in light of the seasonality of flu outbreaks.
Four of these categories comprise exclusively manually-curated associations supported by experimental, computational analysis, author statements or curatorial statements.
The fundamental role of the PI3K pathway in ESCs, as suggested by the computational analysis, is supported by different lines of experimental evidence.
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