breakthrough rate

USAGE SUMMARY

The phrase "breakthrough rate" is correct and usable in written English.
It can be used in contexts related to statistics, research, or performance metrics, often referring to the rate at which significant progress or discoveries are made. Example: "The breakthrough rate in cancer research has significantly increased over the past decade, leading to new treatment options."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

3 human-written examples

The annual breakthrough rate through 7 years ranged from 0.2%to2.3%3% per year; the estimated cumulative event rate was 6.5%.

The Journal of Pediatrics

Comparison of the observed average annual breakthrough rate with the age-adjusted expected annual incidence rate of varicella in unvaccinated children corresponded to an estimated vaccine efficacy of 93.8% to 94.6%.

The Journal of Pediatrics

Results showed that, over the course of 100 pore volumes (PV) for 6 months, mZVI displayed the lowest TCE breakthrough rate (0.0026 PV−1) and highest TCE removal capacity (43.72 mg) but the poorest EE value (25 40%) in saline groundwater.

Science of The Total Environment

Human-verified similar examples from authoritative sources

Similar Expressions

57 human-written examples

CONCLUSION: Although a weekly dapsone regimen of 4 mg/kg produced less hematologic toxicity than a daily regimen of 2 mg/kg, this advantage was offset by a trend toward higher breakthrough rates of PCP.

Duke University

To date, no convincing trial addresses this clinically challenging question, likely because of the very low breakthrough rates observed [ 4– 6].

Clinical Infectious Diseases

Relapse and breakthrough rates for the 12- and 24-week groups were low and consistent with those observed for the same faldaprevir dose in SILEN-C1 (14).

Antimicrobial Agents and Chemotherapy

Overall, the barrier to resistance is lower in genotype 1a than in genotype 1b strains, resulting in higher breakthrough rates in the former [ 17].

BMC Gastroenterology

45 46 Nevertheless, in vivo emergence of resistant mutants conferring cross-resistance to polymerase inhibitors sofosbuvir and mericitabine has been described, 47 and combination of daclatasvir with protease inhibitors was associated with significant viral breakthrough rates.

Gut

When posaconazole is used prophylactically, the performance of galactomannan screening tests is impacted by the very low pretest probability of invasive fungal infection (IFI); in other words, successful prophylaxis results in low IFI breakthrough rates.

Clinical Infectious Diseases

In the elderly population, however, both Western vaccines show relatively good boosting responses, with relatively low breakthrough rates., Nevertheless, older persons (aged > 60 y) face the risk of becoming seronegative earlier because of the lower antibody titer achieved immediately after the booster.

Human Vaccines and Immunotherapeutics

A pharmacy-dispensing analysis in which 10 390 infants who received palivizumab were evaluated showed that when palivizumab compliance was defined as dosing gaps of ≤35 d, RSVH breakthrough rates were higher in noncompliant vs. compliant infants (1.4% vs 3.1%; odds ratio, 2.2 [95% CI: 1.4, 3.5]; P < 0.001).

Human Vaccines and Immunotherapeutics

Expert writing Tips

Best practice

When discussing medical or scientific advancements, use "breakthrough rate" to quantify the speed or frequency of significant discoveries or improvements. It provides a clear metric for evaluating progress.

Common error

Avoid assuming that a high "breakthrough rate" directly implies the effectiveness of a specific intervention without controlling for other contributing factors. Always consider potential confounding variables.

Linguistic Context

The phrase "breakthrough rate" functions as a noun phrase, often used as a subject or object in a sentence to quantify the frequency or pace of significant advancements. Ludwig examples show it used to measure progress in areas like vaccine effectiveness and medical treatment.

Expression frequency: Uncommon

Frequent in

Science

75%

Academia

12%

News & Media

8%

Less common in

Formal & Business

2%

Encyclopedias

1%

Wiki

1%

Ludwig's WRAP-UP

In summary, "breakthrough rate" is a noun phrase used to quantify the frequency of significant advancements, predominantly in scientific and medical contexts. Ludwig AI confirms its correct usage in written English. While the phrase is not exceedingly common, it is valuable for precisely measuring progress and assessing effectiveness. When using "breakthrough rate", avoid implying causation without considering other variables. Alternative phrases include "rate of advancement" and "pace of progress". The phrase appears most frequently in scientific and academic sources, indicating its formal and technical nature.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

rate of advancement

Replaces "breakthrough" with "advancement", highlighting the progress made, and keeps "rate" to indicate the speed of this progress.

percentage of breakthroughs

Expresses breakthrough as part of a whole, quantified using a percentage.

success frequency

Replaces "breakthrough" with "success" focusing on successful outcomes, and "rate" with "frequency" emphasizing how often successes occur.

frequency of discovery

Focuses on the act of discovering new things, replacing "breakthrough" with "discovery" and "rate" with "frequency".

pace of progress

Emphasizes the speed at which progress is happening, replacing both "breakthrough" and "rate" with more general terms.

incidence of innovation

Highlights the occurrence of new ideas and methods, using "incidence" to convey a similar meaning to "rate".

acceleration of progress

Emphasizes the increasing speed of advancements, adding a sense of dynamism.

probability of success

Shifts the focus to the likelihood of achieving success, rather than the rate at which it happens.

degree of advancement

Focuses on how far something has progressed, rather than the rate at which it did.

level of achievement

Highlights the height of the accomplishment, and not the rate in which it happened

FAQs

How can I use "breakthrough rate" in a sentence?

You can use "breakthrough rate" to describe the frequency of significant advancements in a field. For example: "The "breakthrough rate" in cancer treatment has increased in recent years due to advancements in immunotherapy."

What is the difference between "success rate" and "breakthrough rate"?

"Success rate" refers to the proportion of attempts that achieve a desired outcome, while "breakthrough rate" specifically refers to the frequency of significant or transformative advancements.

What are some alternative ways to express "breakthrough rate"?

You can use phrases like "rate of advancement", "pace of progress", or "frequency of discovery" depending on the context.

In what contexts is it appropriate to use "breakthrough rate"?

"Breakthrough rate" is suitable in contexts where you want to quantify the speed or frequency of significant advancements, particularly in fields like science, medicine, and technology.