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Interactions and signaling between these three components are essential for microvessel development during both developmental and pathological neovascularization [ 2– 4].
Intracellular membrane trafficking along endocytic and secretory transport pathways plays a critical role in diverse cellular functions including both developmental and pathological processes.
Although cooperation between several signalling pathways occurs during EMT, signalling by the transforming growth factor β (TGF β) cytokine family has emerged as a key inducer of EMT in both developmental and pathological settings (Xu et al, 2009).
In this review we will discuss recent developments in our understanding of the machinery used by Drosophila hemocytes to chemotax during both developmental and pathological events occurring over the lifespan of a fruit fly.
TGF-β is a major regulator of both developmental and pathological EMT, particularly that in diseased MECs, which frequently exhibit decreased cytostasis and increased invasiveness in response to TGF-β [ 56].
The loss-of-function studies confirmed the effect of miR-132 on endothelial proliferation, tube formation in vitro and both developmental and pathological angiogenesis in vivo via downstream of multiple growth factors involved in regulating endothelial proliferation, migration, and vascular patterning [ 120].
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Indeed, within each individual there are many epigenomes, and these change over time as a consequence of both normal developmental and pathological processes, as well as environmental exposures and random drift.
This is both an important developmental and pathological process, whereby the dissociation of the intercellular junction complexes enables epithelial cells to acquire a mesenchymal phenotype [ 29, 30].
The small bony fish medaka (Oryzias latipes) has attracted increasing attention as a genetic model system to study normal embryonic developmental and pathological processes.
Capillary morphogenesis is a multistage, multicellular activity that plays a pivotal role in various developmental and pathological situations.
Despite their critical role in key developmental and pathological processes, the molecular functions of Nme genes remain poorly documented [3].
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both developmental and functional
both experimental and pathological
both developmental and genetic
both developmental and epigenetic
both developmental and metabolic
both developmental and regenerative
both developmental and potential
both developmental and pathologic
both developmental and stress-responsive
both developmental and postnatal
both healthy and pathological
both beneficial and pathological
both physiological and pathological
both developmental and late-life
both developmental and contextual
both developmental and neuropsychiatric
both developmental and malignant
both developmental and content
both developmental and aging
both developmental and post-developmental
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