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The binding site density of exon 7-1 and 7-2 is lower than the ones of exon 6a and 6b while exon 7-3 is comparable to exon 6a.
The first outgroup, the G clade has a much lower binding site density of 1 and Y. lipolytica an elevated binding site density of 16.
The binding site density of HSPG in the ECM was 750 nM [ 41].
The average binding site density of RTG1/3 in the A clade is 8.6 and highly heterogeneous, V/m = 2.76 (P = 1.4 × 10−3) (fig. 8 E ).
Similar(56)
One mode ranges from 5 to 10 sites and the other consisted of lineages have binding site densities of 1 2.
Given that binding sites were sampled from the 5′ region of eight genes, binding site densities of about 1 2 probably represent spurious binding site distributions, suggesting that this transcription factor is not functional in the methionine pathway of the respective species.
However, the IGR between WD_0100-WD_0102 has only 4 total binding domains (compared to 8) and, due to it's larger size (545 bp) a binding site density 1/3 that of the putative ori (0.007 vs 0.020).
In addition to measurements of cerebral metabolism, PET and SPECT also enable more specific analyses of neurotransmitter binding site density through the use of specific neuroreceptor radiotracers [ 72].
Comparative sequence-based approaches have limited power to detect regulatory regions, in part because of their rapid evolution (Alföldi and Lindblad-Toh, 2013; Lindblad-Toh et al., 2011); indeed, our data indicate that sequence-based features such as sequence constraint or TF binding site density are poor predictors of enhancer conservation.
Plotted in Figure 3B is the ratio, for each distance bin, of the binding site density from the actual data to that of the randomly distributed control.
In order to explore the evolution of binding site density, we computed the mean binding site density and the ratio of binding site variance to mean (V/m ratio) for various clades of yeast species.
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