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Both proteins were expressed inducibly in stably derived clones of 293EcR cells (engineered to express a heterodimeric transcriptional transactivator that only binds to the DNA binding domain present in an inducible promoter in the presence of Pronesterone A, an ecdysone analogue) [ 11].
The hypothesized M1 loop [62] would bring the 3' and 5' ends of 7SK into close proximity of each other and another RNA binding domain present in the C-terminal region of LARP7 could be involved in stabilizing or destabilizing the M1 loop or one particular arrangement of the M2 stem.
The NCBI conserved domain database (CDD) [ 56] indicated a putative DNA binding domain present in the predicted protein sequence.
The PDZ binding domain present in Kirrel3 A may confer Kirrel3 with the ability to alter the polarity of the cell in which it is expressed as the PDZ binding domain of human Kirrel3 is capable of binding to the cell polarity protein partitioning defective 3 (PARD3) [ 39].
Similar(56)
None of these genes include the DNA binding domains present in WD0622, suggesting that even if they are functional their activity is likely to differ significantly from that of their counterpart in wMel.
The C-terminus of FXR1P tested here is the longest form expressed in brain, which nonetheless lacks the G-quadruplex-binding domain present in muscle isoforms.
Peptide crosslinking, a transpeptidation reaction, is the crucial penicillin-sensitive step carried out by the transpeptidase/penicillin-binding domain present in all PBPs.
The LysM domain is a ubiquitous, murein-binding domain present in proteins of both prokaryotes and eukaryotes (Bateman and Bycroft 2000; Buist et al. 2008).
Six of the Arabidopsis kinesins have a calponin homology domain (2.88e-49 to 2.89-16), whish is an actin-binding domain present in the N-termini of spectrin-like proteins.
THAP is a DNA-binding domain present in TPases of the P superfamily; this domain includes a Zn-coordinating C2CH signature and four other invariant residues (P, W, F, and P) that are also required for DNA binding [ 8].
How LUBAC recruitment to the TNF-RSC influences signaling outcome is not known in detail, but it is known that NEMO, which is the regulatory component of the kinase complex that activates NF-κB, recognizes linear ubiquitin chains through its specialized ubiquitin-binding domain, UBAN (ubiquitin-binding domain present in ABINs and NEMO) [ 17, 34].
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