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Although Sox2 does not respond to the reporter in RU cells, possibly due to the fact that Sox2 in RU cells cannot bind to the Sox2 binding motif present in the Sox2 reporter [ 39], Sox2 in RU cells can bind to the alternative Sox2 binding motif present in the Twist1 gene promoter and thus suppress its expression as well as invasiveness.
All target genes had this core binding motif present in their upstream sequences except for two of the ten target genes, which had binding motifs that differed from the consensus binding motif in two nucleotides, namely, TTTTAAC and AGTTTCC.
Using the CLIP approach we were able to not only identify potential RNA targets for SF2/ASF but also define a consensus binding motif present in exonic binding sites (Fig. 3).
The final four amino acids of CRB-3 are EGLI, and hence differ from the canonical ERLI PDZ-domain binding motif present in most Crumbs proteins.
Lacticin 481, a tricyclic lantibiotic, contains a lipid II binding motif present in related compounds such as mersacidin and nukacin ISK-1.
Recent evidence has highlighted an important role for specific integrin receptors in modulating activation of TGF-β via binding to an RGD integrin binding motif present in the latency-associated peptide (LAP) region of latent TGF-β.
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Unlike GAS, but similar to the chromosomal positioning in GCS and GGS [36], the S. iniae scpI gene is located outside of the Mga-like locus of the chromosome (Fig. 2B) and does not possess an upstream promoter region similar to binding motifs present in Mga-regulated GAS scpA genes [14].
VEGF has been successfully delivered via scaffolds utilizing specific binding motifs present in heparin.
The experimental design was based on previously reported binding motifs present in parent peptide 4044 amino acid sequence (K NESK YSNTF INNAYNMSIR), derived from the MSA-2 antigen, which has been previously described by Ocampo et al. (2000).
Potential binding motifs present in this region are: a site for interferon regulatory factor-1 at -1030, an AP-4 site at -978, a thyroid hormone beta receptor binding element (TRE) at -962, another E box at -954, a binding site for the potent repressor CTF/NF-I at -859 [ 29], and a Drosophila homeotic gene Antennapedia binding motif [ 30] at -786.
Ducoux, M. et al. Mediation of proliferating cell nuclear antigen (PCNA -dependent DNA rePCNA -dependentgh a conserveDNA21(Cip1)-like PCNA-binding motif preplicationhe throughubunit of human DNA polymerase delta.
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