bind to the backbone

USAGE SUMMARY

The phrase "bind to the backbone" is correct and usable in written English.
It can be used in contexts related to biology, chemistry, or technology, where something is attaching or connecting to a central structure or framework. Example: "The new drug is designed to bind to the backbone of the DNA molecule, enhancing its effectiveness in targeting cancer cells."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

1 human-written examples

A key difference would appear to be that Ni II) does not bind to the backbone amide between Ile1 and Gln2, whereas Cu II) does.

Biochemistry

Human-verified similar examples from authoritative sources

Similar Expressions

59 human-written examples

In our structure, the NO2 and NO3 of the nicotinamide ribose interacts with E385 and K338 respectively; while NO7 of the nicotinamide ring binds to the backbone of L255 and G232 of the catalytic domain (Figure 6, Table S2).

Plosone

Many of these techniques are still bound to the backbone of wire at some level.

Critical Care

As described previously [ 24], the transamide carbonyl oxygen of MELK-T1 binds to the backbone NH of Cys89 in the hinge region of the catalytic domain of MELK.

Bioscience Reports

While in the protonated state Asp30 binds to the backbone C=O of Leu130 (part of the G-H loop), it is detached upon deprotonation leading to the opening of the heme pocket.

F1000Research

10a Again, those water molecules share the same binding motifs: HOH794 binds to the side chain carboxamide NH of Asn 194, and HOH822 binds to the backbone NH of Phe 231 as well as to the side chain amino functionality of Lys 119.

ChemMedChem

These residues responsible for ssDNA and dsDNA binding are almost overlapped; thus, PriB may use a similar approach to bind to the phosphate backbone of ssDNA and dsDNA through several positively charged residues.

BioMed Research International

One of the probes has been designed to bind to the silica backbone, while the other has been designed to bind to the transition metal species.

Journal of Electroanalytical Chemistry

Here we wish to suggest a structure-based re-demarcation of the TALE repeat which starts with the residues that bind to the DNA backbone phosphate and concludes with the base-recognition hyper-variable residue.

Protein & Cell

For geometrical reasons, NQTrp does not frequently bind to the Phe19 backbone.

Plosone

Single zinc fingers bind to the RNA backbone without sequence specificity, forming complexes with contacts between the RNA minor groove and residues in the N-terminal β strands and between the major groove and residues in the helix kink helix motif.

Biochemistry

Expert writing Tips

Best practice

When using "bind to the backbone" in scientific writing, clearly specify what is binding and to which backbone it is binding to avoid ambiguity. For example, "the antibody binds to the protein backbone".

Common error

Avoid using "bind to the backbone" without sufficient context. Ensure the reader understands the specific molecular or structural context you're referring to, as the term can be too broad without clear referents.

Linguistic Context

The phrase "bind to the backbone" functions as a verb phrase, typically used within a larger sentence to describe an interaction where one entity attaches or connects to a foundational or structural element. As shown in Ludwig, this phrase is frequently used in scientific literature.

Expression frequency: Uncommon

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

In summary, the phrase "bind to the backbone" is a grammatically correct verb phrase primarily used in scientific contexts to describe the attachment of one entity to the structural framework of another. As Ludwig AI confirms, it's most frequently found in scientific literature. While the phrase itself is straightforward, clarity is crucial; specify what is binding and to what backbone. Alternatives like "attach to the framework" or "connect to the structure" can be used depending on the specific nuance you want to convey.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

attach to the framework

Focuses on the act of attaching to a supporting structure rather than a specific biological backbone.

connect to the structure

Emphasizes a connection rather than a specific binding action.

link to the core

Highlights a linking action to a central element.

adhere to the main chain

More specific to polymeric or molecular structures, highlighting adhesion to the primary chain.

associate with the skeleton

Uses "skeleton" metaphorically, suggesting a structural framework.

anchor to the base

Implies a strong, fixed attachment to a foundational part.

join to the spine

Uses "spine" as a metaphor for the main supporting structure.

couple to the support

Emphasizes a coupling action to provide support.

affix to the mainframe

Refers to a mainframe, often in technological contexts, signifying a primary structure.

fasten to the matrix

Highlights a fastening action within a matrix, a surrounding structure.

FAQs

How can I use "bind to the backbone" in a sentence?

Use "bind to the backbone" to describe the interaction where one molecule or entity attaches to the central structural component of another, for example: "The drug is designed to "bind to the backbone" of the virus's RNA".

What does "bind to the backbone" mean in molecular biology?

In molecular biology, "bind to the backbone" refers to the interaction where a molecule attaches to the structural framework of a larger molecule, such as the phosphate backbone of DNA or the polypeptide backbone of a protein.

What are some synonyms for "bind to the backbone"?

Alternatives to "bind to the backbone" include "attach to the framework", "connect to the structure", or "link to the core", depending on the specific context you want to emphasize.

Is it more accurate to say "bind to the backbone" or "binds to the backbone"?

The correct form depends on the subject of the sentence. Use "bind to the backbone" when the subject is plural (e.g., "These proteins bind to the backbone"), and "binds to the backbone" when the subject is singular (e.g., "This protein binds to the backbone").