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"big limitations" is correct and usable in written English.
It is usually used in a context referring to a challenge or obstacle that is difficult to overcome. For example, "Although the proposed plan has potential, it also has some big limitations that must be addressed."
Exact(9)
Even if big limitations on asbestos lawsuits are not passed, businesses in general will gain from a more conservative federal judiciary, he said.
While the study is interesting, Dr. Goldstein said, it has some "big limitations," in that it is based on a very small number of patients and they were not compared with a control group.
The production world right now is dealing with two big limitations.
"I have big limitations of my arm which don't allow me to test in single-seaters," Kubica said.
The iPhone still has big limitations that make it less useful for business users, particularly battery life.
Despite these seemingly big limitations, the setup provides an environment free from these potentially confounding effects, allowing analysis to focus only on the assessment of the perfusion dynamics within the cardiac compartments, and the potential to repeatedly examine count-rate capability for determination of perfusion accuracy.
Similar(51)
This is called recall bias and is a big limitation of such studies.
"I tell young physicians who are starting out here that the big limitation is imagination," said Dr. Martin Raber, an oncologist — and a cancer patient himself — at Anderson.
"The big limitation on all of this, when we're talking about treating the forest, is economics," said Mr. Knopp, the Forest Service supervisor.
But, as a strategy for managing carbon emissions, these recovering forests have one big limitation: the planet simply does not have room for many more of them.
"Not having natural sunlight is a big limitation when you want to do plant biology," said Kristina Yu, director of the Exploratorium's living systems department.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com