Indeed, invasive reference examinations, such as biopsy, can be inconclusive, are non-representative of the whole tissue (which is a tremendous limitation when assessing malignant tumours, which are known to be heterogeneous) and possess non-negligible levels of mortality and morbidity.
There are tremendous resource limitations and challenges in driving research and drug development for rare diseases.
In order to overcome the limitation, tremendous efforts have been given on micromixers, as summarized in the following.
Owing to this limitation, tremendous efforts have been made to introduce new sources of resistance from wild tetraploids, such as emmer (T. diccoccum), Persian (T. cathalicum), and Polish (T. polanicum), and from common wheat sources, such as Sumai3, to durum wheat with limited success (Garvin et al. 2009; Kumar et al. 2007).
Although such methods have shown tremendous success, they have limitations that impact their generality.
Though the reforms in Vietnam have led to tremendous economic growth, challenges and limitations in the implementation of the new economic policies remain.
Despite the military success of Desert Storm, the Army's logistics leaders realized that relying on tremendous mass had costs and limitations.
While GO analysis offers tremendous value, it also has limitations, such as the lack of direct association with pathways.
While GO offers tremendous value, it also has limitations, such as the lack of direct association with pathways.
