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Designing classifiers that achieve optimal differential response between specific cell types is a hard computational problem because it involves selection of endogenous inputs and optimization of both biochemical parameters and a logic function.
This report presents the first study of prostate tumor tissue that examines patterns of differential expression between specific cell types using laser capture microdissection (LCM).
Alternatively, the Rac-FRET mouse could be crossed to a strain expressing a red fluorescent protein specifically in a cell type of interest, for in vivo colabeling and comparing Rac activity between specific cell types within complex tissues.
Mouse models of these mutations can now be investigated using increasingly powerful and sophisticated tools to get at the underlying neurobiology and elucidate pathogenic mechanisms, from the level of synapses formed between specific cell types in specific circuits to the level of dynamic function of neuronal networks and concomitant moment-to-moment behavior.
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The ability to generate, differentiate, and profile adult stem cells provides a powerful but underutilized opportunity to investigate the molecular basis for trait differences between species within specific cell types and in a controlled environment.
Currently, there are several AAV serotypes available that can be used for tissue enrichment based on natural tropism toward specific cell types and interaction between different cellular receptors and serotypes.
Regulatory elements in miRNA promoters are less well studied, but may reveal a link between their expression and a specific cell type.
And you need a specific cell type for a specific disease.
The expression in the stroma did not appear to be specific to any specific cell type.
These stem cells mature into specific cells types, such as heart, nerve or skin cells, as the fetus develops.
LAX is mainly expressed in B cells, T cells, and other lymphoid-specific cell types.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com