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Tumors always encompass both malignant part and non-malignant cells of various cell lineages with complex mutual interactions between particular cell types [ 2, 40].
Cell wall glycoproteins are structural components vital for cell wall biogenesis and the glycoprotein content of cell walls varies between particular cell types, allowing specialized adaptation to specific environmental stresses (Latgé 2007; Sosinska et al. 2009).
Indeed, the Km for taurine transport by system β varies quite considerably between different cell types from the same species (in some cases over 10-fold) and between particular cell types isolated from different species [24].
A cell-specific approach has the potential to address the question of gene expression differences between particular cell types in stable and unstable plaques with greater precision than approaches based on the study of whole plaques.
In addition to compounds with differential toxicity between particular cell types in the two species, we were able to identify compounds that were generally cytotoxic either toward rodent or human cell types (determined by a t-test on IC50 values of the nine human versus the four rodent cell types).
Similar(55)
For studies aiming to investigate specific histological regions (e.g. interface between tumor and stroma) or particular cell types, conventional TMAs fall short.
In this regard, marked differences in the response to apoptotic stimuli between TKO and DKO cells may only be seen in particular cell types.
Whether DAI exerts its DNA sensing role in particular cell types still remains elusive.
Alternatively, particular cell types can be detected in vivo by expression of fluorescent proteins from cell type-specific promoters.
Figure 9 schematically illustrates our findings with each enzyme specifically expressed by particular cell types.
Pluripotent stem cells can be influenced to differentiate into particular cell types when grown over more mature cells [11].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com