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These findings provide new insights into the role of the ETS transcriptional network in prostate tumorigenesis and uncover previously unrecognized links between aberrant expression of ETS factors, deregulation of epigenetic effectors and silencing of tumor suppressor genes.
Thus, the correlation between aberrant expression of CXCR2 and the poor prognosis of the patients was possibly due to its angiogenic role in gastric cancer.
The relationship between aberrant expression of cyclin D1 and retinoblastoma (RB) protein and clinicopathological factors was investigated in 80 patients with oesophageal SCC using immunohistochemical analyses.
A number of studies have concentrated on the connection between aberrant expression of GST isozymes, including GST Pi isozymes, with the development and expression of resistance to chemotherapy drugs as reviewed by McIlwain et al.[ 13].
An interesting and novel finding in the present study is the correlation between aberrant expression of the studied markers and the OS rates and the use of marker combination for the assessment of the clinical outcome of patients.
Previous studies have documented the relationship between aberrant expression of FUT4 in epithelial cells and constitutive activation of Akt and NF- κB, whose pathways are involved in the regulation of EMT and the promotion of metastasis.
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For many years researchers had observed a link between the aberrant expression of MUC1 and cancer.
The present study demonstrated an association between the aberrant expression of P-cadherin and a malignant phenotype, higher histological grade and invasive behaviour, suggesting that this protein may constitute a reliable independent biomarker of poor prognosis in feline mammary tumours.
MCL1 (myeloid cell leukemia 1), a prosurvival member of the Bcl-2 family, was expected to be important due to the association between the aberrant expression of prosurvival Bcl-2 family proteins, tumorigenesis, and resistance to chemotherapeutics [ 20].
The clinical importance of tension in wound-scar formation [ 62] and postoperative management of DD patients [ 46], coupled with the tension-dependent changes in β-catenin levels observed in this study, suggests a possible mechano-chemical link between the aberrant expression of β-catenin in DD lesions [ 13] and tension-induced scar formations in fibro-proliferative disorders like DD.
However, a mechanistic link between aberrant expression and cancer has remained elusive.
Related(11)
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