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There is a strong association between elevated expression of SPARC and tissue scarring and fibrosis.
A positive correlation was also found between elevated expression of plakoglobin and vascular invasion (Endo et al, 2000).
However, we did not observe the direct evidence of the correlation between elevated expression of PLD and thyroid epithelial growth/differentiation.
The study revealed a link of potential mechanistic significance between elevated expression of STAT1 and its target genes with markers of infiltrating immune cells, in particular with tumor-associated macrophages.
Wnt-5a is expressed constitutively in pellet cultures in vitro (GBoland et al., unpublished observation), whereas in rheumatoid arthritis, there is an established connection between elevated expression of Wnt-5a by activated synovium and established disease markers [ 90].
The correlations between elevated expression of hnRNP K and tumour development and progression are well documented (Carpenter et al, 2006a) and the results reported here are in line with those findings.
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The results revealed an intimate relationship between the elevated expression of aPKC ι and the formation and maintenance of EMT.
To clarify the relationship between the elevated expression of EVI1 in HCC tumors and various clinicopathological parameters, we correlated the EVI1 expression level with available clinical data.
This observation was consistent with earlier studies reporting a significant correlation between the elevated expression of SPARC mRNA and poor prognosis [10].
Taken together, these correlations with BMP-4 and CK8 support an association between elevated miR-143 expression and elevated expression of columnar cell markers in reflux-exposed squamous mucosa.
Finally, we observed a close correlation between the high frequency of p53 mutations and the elevated expression of NF-κ B target genes in breast tumors.
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