These results suggested that MAPK activities may be increased in the adenoma-to-carcinoma sequence and that it may play a role in the tumour progression.
While the length of the analyzed sequence can be increased in DiGReF, this significantly increases the computation time and was therefore not done in this initial study.
It has also been suggested that the substitution rate is increased in SSR sequences (Shankar et al. 2007; Pumpernik et al. 2008) as well as in their flanking regions (Siddle et al. 2011).
Our results support the proposed hypothesis as self- biotinylation is competitively inhibited by biotin acceptor molecule which is is increased in the presence of operator sequence of biotin biosynthetic pathway [18].
In summary, the current studies have demonstrated that the expression of autoantibodies directed against the epitopes of ribosomal P proteins other than the C-terminal 22-amino acid sequence is increased in CSF from patients with diffuse NP-SLE.
This can be explained by the number of unique sequences that are increased in the mutated datasets compared with the original one.
Except for the Borrelia burgdorferi sequence, the mean scaled delta-distance is increasing in window size for every sequence.
