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Thus, loss of ASS expression may be both prognostic and potentially predictive of response to arginine deprivation therapy.

There may be both prognostic and therapeutic information in determining the site of origin of metastatic lesions.

CMTC was found to be both prognostic and predictive in a large external breast cancer cohort in that study.

The 21-gene recurrence score has been shown to be both prognostic and predictive of the benefit of adding chemotherapy to tamoxifen.

Apart from representing potential therapeutic targets for novel, TRAIL-based therapies, the two TRAIL receptors and their expression pattern may be both prognostic and predictive for patient survival.

Elevated levels of serum HER2 ECD have been shown to be both prognostic and predictive of response to trastuzumab in HER2-positive tumors [ 36, 37].

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Similar(52)

Thus, the total score appears to contain elements that are both prognostic and diagnostic of OA characteristic of hip dysplasia.

For markers that are both prognostic and predictive the absolute benefit is not necessarily correlated with the risk.

About 20 25 % of breast cancers have overexpression of HER2 [ 10, 11] which is both prognostic and predictive of treatment benefit.

During the past decade, the focus of research has been on finding a gene signature that is both prognostic and predictive with high accuracy while containing only a small number of genes.

We previously published on repeated measurements of circulating caspase-cleaved and total cytokeratin 18 (ctCK18; tCK18), as biomarkers of epithelial cell death, in patients with metastatic colorectal cancer (mCRC) undergoing conventional chemotherapy, and provided evidence that serum concentrations of tCK18 are both prognostic and PD (Greystoke et al, 2012).

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