Importantly, regardless of whether our model over- or under-estimates the exact posterior variance about the network, we find points in the latent variable space that are both predictive and parsimonious, largely agreeing with the human anatomists and predicting existing connections.
CMTC was found to be both prognostic and predictive in a large external breast cancer cohort in that study.
Apart from representing potential therapeutic targets for novel, TRAIL-based therapies, the two TRAIL receptors and their expression pattern may be both prognostic and predictive for patient survival.
Interestingly, COL1A1 has been shown to be both prognostic and predictive in multiple cancer types, including breast cancer [ 3, 5, 64, 65].
Elevated levels of serum HER2 ECD have been shown to be both prognostic and predictive of response to trastuzumab in HER2-positive tumors [ 36, 37].
The 21-gene recurrence score has been shown to be both prognostic and predictive of the benefit of adding chemotherapy to tamoxifen.
Thus, loss of ASS expression may be both prognostic and potentially predictive of response to arginine deprivation therapy.
We found that the two site-related parameters were both predictive for outcome, and there was a significant relationship between chest and finger tip site-related parameters.
After controlling for traditional cardiovascular risk factors in multivariable regression models, IL-6 was predictive of all three biomarkers of endothelial dysfunction, and rheumatoid factor titre and low GFR were both predictive of VCAM-1 and ICAM-1 (Table 5).
We confirm that TFs and HMs are both predictive of gene expression (measured by mRNA transcript abundance) and statistically redundant at a genome-wide level.
