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An additional 240 mutants previously shown to be attenuated in a chronic model of rat lung infection were also screened [19].

Hyaluronidase mutants do not appear to be attenuated in a murine model of meningitis after intracerebral infection [100], suggesting that this degradative enzyme may be important for the bacteria to cross the mucosa or the BBB during the early stages of pathogenesis.

Also, sapD mutants of non-typable H. influenzae have been shown to be attenuated in a chinchilla model of otitis media [87]. A. pleuropneumoniae possesses a complete sap operon, which could have significant role in the survival of the pathogen in the host.

Interestingly, the pro-metastatic effects of sunitinib could be attenuated in a breast cancer model by adopting a "condensed" drug schedule, in which a further higher dose (120 mg/kg) was administered for a shorter time before surgery.

Thus, one could speculate that the efficacy of Notch localization and signaling may be attenuated in a baz mutant background, where the systems regulating polarity are highly sensitized, therefore resulting in mild PFC multilayering.

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As we used endothelium-denuded arterial rings in the current study, mepivacaine-induced vasoconstriction would be attenuated in an in vivo vessel with its endothelium intact.

More than that, if the benefits of a treatment are attenuated in a trial, because of a delay introduced by the demands of ethics committees, then the trial gives the wrong answer.

Additionally, interleukin-6 response was attenuated in a colorectal surgery study using a Doppler-optimized goal-directed fluid management [85].

The refractive index is related to how much the speed of light is reduced through a material, compared to the vacuum speed, and the dielectric constant tells us how much the electric field is attenuated in a substance, compared to vacuum.

Also the tpx mutant was attenuated in a mouse peritonitis model [26].

In F. tularensis, a recent study found that an Hfq mutant of a subspecies holarctica strain contributed to its stress tolerance and was attenuated in a mouse model [61].

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