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The active investigation of pharmacologic demethylating agents as therapy for malignancy based on reversal of silencing of tumor suppressor genes may have unintended effects.
In bottom panel, τ = −1 where α and β are defined in Equations 3 and 4. Equivalent activation parameters were used to implement either a sodium or potassium current based on reversal potential.
For measurement of excitation/inhibition (E/I) balance, sEPSCs and sIPSCs were isolated in the same cell based on reversal potentials of GABAAR-mediated and AMPAR-mediated currents, respectively.
Positive transformants were selected on the basis of auxotrophies complemented by heterolous orthologues of pyrG89 or riboB2 (e.g., complementation of pyrG89 by the pyr-4 gene from N. crassa in pRG3-AMA1 plasmins in media lacking pyrimidines), or for mutant sltB strains based on reversal of sensitivity to elevated concentrations of potassium (0.6 M KCl) in the media.
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All comedy is based on reversals, where you take the audience's expectations and challenge them.
The quantitative component is based on a reversal longitudinal design.
"Everyone thought that the market was going to pull back this morning, based on that reversal to the downside that we saw on the Dow and the Standard & Poor's 500 yesterday, and the pullback really couldn't gain any momentum," says Clark.
We calculated the excitatory and inhibitory components of the conductance based on a reversal potential of 0 mV for excitation and −69 mV for inhibition (Figure 2E & F, see Methods).
The total synaptic conductance is determined from the slope of the resulting IV curve and the E/I ratio is calculated based on the reversal potential of the curve [4], [5], [6], [7].
Based on the reversal potential, the channel is about five-fold selective for K+.
A summed score was calculated based on a reversal of the efficacy items and evaluated on a scale ranging from 0 (indicating 'no burnout') to 90.
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