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Among the five heterogeneous variances MTC model, the informed variances model based on frequentist approximate distributions produced variance estimates closest to the frequentist ones and had the posterior variance distributions with the highest precision.
The informed variance model based on frequentist approximate distributions yielded the best model fit according to the DIC.
In this example, a number of reasons suggest the informed variances model based on frequentist approximate variance distributions is the more optimal choice.
The unrestricted variances model had the widest credible intervals among the heterogeneous variances models, and the informed variances model based on frequentist approximate distributions had the narrowest credible intervals.
For the comparison between peginterferon-2a and interferon and the comparison between the two peginterferons, the homogeneous variance model has narrower 95% credible intervals that all other heterogeneous variance models, except for the informed variance model based on frequentist approximate distributions (see Table 2).
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Patients were classified into two response groups based on frequentist mixture analysis using the total Alda scale score.
Patients were classified into good responders and moderate/poor responders as defined based on frequentist mixture analysis using the total Alda scale score.
Based on frequentist mixture analysis of the total score, 27 (33.8%) and 53 (66.2%) patients were classified into the good response and moderate/poor response groups, respectively.
Lerche shows that a repeated significance test boundary based on frequentist principles is also an optimal Bayesian boundary when the decision loss is 0 1 and the sampling cost per unit time is cθ2 with c>0.
Methods based on frequentist statistical inference are also less than ideal in the context of epistasis.
Table 3 compares the pharmacokinetic parameters and demographics in patients with and without hearing loss, based on frequentist statistical inferences.
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Justyna Jupowicz-Kozak
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